       Document 0127
 DOCN  M9630127
 TI    Functional brain imaging in HIV-1-infected children born to seropositive
       mothers.
 DT    9603
 AU    Depas G; Chiron C; Tardieu M; Nuttin C; Blanche S; Raynaud C; Syrota A;
       Service Hospitalier Frederic Joliot, CEA and INSERM U29, Orsay,; France.
 SO    J Nucl Med. 1995 Dec;36(12):2169-74. Unique Identifier : AIDSLINE
       MED/96101642
 AB    The aim of this work was to study cerebral function in vertically
       infected children with human immunodeficiency virus 1 (HIV-1). METHODS:
       PET with 18F-labeled fluorodeoxyglucose (FDG) was performed in eight
       children (2.5-5.5 yr): three with severe neurological symptoms and five
       without. Quantitative analysis was based on gray matter cortical and
       subcortical regions of interest for which glucose utilization was
       measured. RESULTS: Diffuse hypometabolism and subcortical
       hypermetabolism were found in the three children with severe
       neurological signs; the five other children had temporo-occipital
       cortical hypometabolism, mainly on the right side. CONCLUSION:
       Functional cerebral abnormalities seem to precede clinical symptoms in
       HIV-1infection of the brain in children.
 DE    Acquired Immunodeficiency Syndrome/TRANSMISSION  AIDS Dementia
       Complex/*RADIONUCLIDE IMAGING  Brain/*RADIONUCLIDE IMAGING  Case-Control
       Studies  Child, Preschool  Deoxyglucose/*ANALOGS &
       DERIVATIVES/DIAGNOSTIC USE  Disease Transmission, Vertical  Female
       Fluorine Radioisotopes/*DIAGNOSTIC USE  Human  HIV Seropositivity
       *HIV-1  Male  Support, Non-U.S. Gov't  *Tomography, Emission-Computed
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

