       Document 0126
 DOCN  M9630126
 TI    Abnormal gallium-67 skull uptake: a sign of peripheral marrow activation
       in HIV-positive patients with disseminated mycobacterioses.
 DT    9603
 AU    del Val Gomez M; Gallardo FG; Cobo J; Castro-Beiras JM; Nuclear Medicine
       Service, Institute of Health Carlos III, Madrid,; Spain.
 SO    J Nucl Med. 1995 Dec;36(12):2211-3. Unique Identifier : AIDSLINE
       MED/96101650
 AB    The purpose of this study was to investigate the significance of
       abnormal 67Ga-citrate skull uptake in AIDS patients with
       mycobacterioses. METHODS: Gallium-67 scans of 39 HIV-positive patients
       who have been diagnosed with mycobacterioses were analyzed; the scans of
       15 consecutive HIV-positive patients without mycobacterioses were also
       reviewed as a control group. The skull was chosen to assess bone marrow
       uptake because of the absence of overlapping structures. RESULTS:
       Twenty-nine of 39 (74%) patients with mycobacterial infections had
       disseminated disease. Gallium-67 uptake in the skull was visualized in
       24 of these 29 patients (82%). One of the patients without disseminated
       disease and one patient in the control group (n = 15) showed skull
       uptake. CONCLUSION: Abnormal 67Ga skull uptake appears to be a sensitive
       (82%) and specific (82%) indicator of disseminated mycobacterial
       infection in HIV-positive patients.
 DE    Adult  AIDS-Related Opportunistic Infections/MICROBIOLOGY/*RADIONUCLIDE
       IMAGING  Bone Marrow/*RADIONUCLIDE IMAGING  Case-Control Studies
       Citrates/*DIAGNOSTIC USE  Female  Gallium Radioisotopes/*DIAGNOSTIC USE
       Human  Male  Mycobacterium avium-intracellulare Infection/*RADIONUCLIDE
       IMAGING  Prospective Studies  Skull/*RADIONUCLIDE IMAGING  Tuberculosis,
       Miliary/*RADIONUCLIDE IMAGING  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

