       Document 0125
 DOCN  M9630125
 TI    [Two cases of sensory neural hearing loss as a manifestation of HIV
       infection]
 DT    9603
 AU    Ohashi S; Hiraide F; Funasaka S; Fujita H; Yoshiura K; Hagiwara A; Fukue
       H; Fukutake K; Department of Otorhinolaryngology, Tokyo Medical College.
 SO    Nippon Jibiinkoka Gakkai Kaiho. 1995 Sep;98(9):1399-406. Unique
       Identifier : AIDSLINE MED/96021717
 AB    In patients with HIV infection, oral and pharyngeal pathology frequently
       occurs, but there have been no reports on cases of deafness in Japan.
       Herein, the authors report two cases of sensory neural hearing loss in
       hemophilia A patients infected with HIV through factor VIII
       concentrates. Case 1 was a 16-year-old male with hemophilia A. He had
       been administered factor VIII concentrates starting at 6 months after
       birth. At 8 years of age, HIV antibodies were positive. He was diagnosed
       as having AIDS after suffering from pneumocystis carinii. He complained
       of right otalgia and slight vertigo during treatment for a relapse of
       the pneumocystis carinii. He underwent otological examinations at our
       department. The right tympanic membrane showed opacification and serous
       otorrhea was noted. Acute otitis media was diagnosed and tympanotomy was
       conducted. Afterwards, the right tympanic membrane developed a large
       perforation and sensory neural hearing loss occurred. Case 2 was a
       49-year-old male with hemophilia A. He had been administered factor VIII
       concentrates from the age of 23 years. At 48 years of age, HIV
       antibodies were positive. The patient complained of sudden deafness in
       the right ear and slight vertigo. He underwent otological examinations
       at our department. The tympanic membrane was normal bilaterally, but
       sensory neural hearing loss was found in the right ear. It was presumed
       that acute otitis media directly involving the inner ear had caused a
       perceptive disorder in case 1 while a pattern of sudden onset of
       deafness was apparent in case 2.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/TRANSMISSION
       Adolescence  Case Report  English Abstract  Factor VIII/ADVERSE EFFECTS
       Hearing Loss, Sensorineural/*ETIOLOGY  Hemophilia/COMPLICATIONS  Human
       Male  Middle Age  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

