       Document 0102
 DOCN  M9630102
 TI    Vaccination protects against in vivo-grown feline immunodeficiency virus
       even in the absence of detectable neutralizing antibodies.
 DT    9603
 AU    Matteucci D; Pistello M; Mazzetti P; Giannecchini S; Del Mauro D;
       Zaccaro L; Bandecchi P; Tozzini F; Bendinelli M; Department of
       Biomedicine, University of Pisa, Italy.
 SO    J Virol. 1996 Jan;70(1):617-22. Unique Identifier : AIDSLINE
       GENBANK/M25381
 AB    So far, vaccination experiments against feline immunodeficiency virus
       have used in vitro-grown virus to challenge the vaccinated hosts. In
       this study, cats were vaccinated with fixed feline immunodeficiency
       virus-infected cells and challenged with plasma obtained from cats
       infected with the homologous virus diluted to contain 10 cat 50%
       infectious doses. As judged by virus culture, PCRs, and serological
       analyses performed over an 18-month period after the challenge, all of
       the vaccinated cats were clearly protected. Interestingly, prior to
       challenge most vaccines lacked antibodies capable of neutralizing a
       fresh isolate of the homologous virus.
 DE    Amino Acid Sequence  Animal  Antibodies, Viral/*BLOOD/IMMUNOLOGY  Base
       Sequence  Cats  Cell Line  DNA Primers  Feline Acquired Immunodeficiency
       Syndrome/*PREVENTION & CONTROL  Female  Immunodeficiency Virus,
       Feline/*IMMUNOLOGY/ISOLATION & PURIF  Molecular Sequence Data
       Neutralization Tests  Repetitive Sequences, Nucleic Acid  Support,
       Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY  Viral Vaccines/*ADMINISTRATION
       & DOSAGE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

