       Document 0098
 DOCN  M9630098
 TI    Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction
       through DNA vaccination of rhesus monkeys.
 DT    9603
 AU    Yasutomi Y; Robinson HL; Lu S; Mustafa F; Lekutis C; Arthos J; Mullins
       JI; Voss G; Manson K; Wyand M; Letvin NL; Division of Viral
       Pathogenesis, Beth Israel Hospital, Harvard; Medical School, Boston,
       Massachusetts 02215, USA.
 SO    J Virol. 1996 Jan;70(1):678-81. Unique Identifier : AIDSLINE
       MED/96099492
 AB    In view of the growing evidence that virus-specific cytotoxic T
       lymphocytes (CTL) play an important role in containing the early spread
       of human immunodeficiency virus type 1 (HIV-1) in infected individuals,
       novel vaccine strategies capable of eliciting HIV-1-specific CTL are
       being pursued in attempts to create an effective AIDS vaccine. We have
       used the simian immunodeficiency virus of macaques (SIVmac)/rhesus
       monkey model to explore the induction of AIDS virus-specific CTL
       responses by DNA vaccination. We found that the inoculation of rhesus
       monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a
       persisting SIVmac-specific memory CTL response. These CTL were CD8+ and
       major histocompatibility complex class I restricted. These studies
       provide evidence for the potential utility of DNA inoculation as an
       approach to an HIV-1 vaccine.
 DE    Animal  DNA, Viral/ADMINISTRATION & DOSAGE/*IMMUNOLOGY  Gene Products,
       env/GENETICS/IMMUNOLOGY  Histocompatibility Antigens Class I/IMMUNOLOGY
       Macaca mulatta  Plasmids  Retroviridae Proteins/GENETICS/IMMUNOLOGY
       Support, U.S. Gov't, P.H.S.  SIV/GENETICS/*IMMUNOLOGY  T-Lymphocytes,
       Cytotoxic/*IMMUNOLOGY  Tumor Cells, Cultured  Vaccines,
       Synthetic/ADMINISTRATION & DOSAGE/IMMUNOLOGY  Viral Envelope
       Proteins/GENETICS/IMMUNOLOGY  Viral Vaccines/ADMINISTRATION &
       DOSAGE/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

