       Document 0081
 DOCN  M9630081
 TI    Cytomegaloviraemia and T cell subpopulations in renal transplant
       patients.
 DT    9603
 AU    Aguado S; Tejada F; Gomez E; Gago E; Tricas L; de Ona M; Alvarez-Grande
       J; Servicio de Nefrologia, Hospital Covadonga, Oviedo, Spain.
 SO    Nephrol Dial Transplant. 1995;10 Suppl 6:120-1. Unique Identifier :
       AIDSLINE MED/96053001
 AB    We studied 54 consecutive recipients of renal transplants to evaluate
       their immunological responses to cytomegalovirus (CMV) infection.
       Forty-three (79.6%) patients developed CMV infection, and all of them
       subsequently recovered. Fourteen of these infected patients (32.6%)
       developed viraemia during the infectious process, four of whom then
       manifested the disease. The number of lymphocytes and their main
       subpopulations was normal before the appearance of CMV infection. During
       the infection there was a significant growth (P < 0.001) in the CD8+DR+
       subset, corresponding to activated T suppressor/cytotoxic lymphocytes,
       whereas the natural killer measured subsets remained within normal
       limits during the whole infectious process. As all viraemic patients
       recovering from the infection developed CD8+DR+ activation, we conclude
       that this recovery is associated with the immunological activation.
 DE    Adult  Cytomegalovirus Infections/*ETIOLOGY/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Female  Human  HLA-DR Antigens/METABOLISM
       Kidney Transplantation/*ADVERSE EFFECTS/*IMMUNOLOGY  Lymphocyte
       Transformation  Male  Middle Age  T-Lymphocyte Subsets/*IMMUNOLOGY
       Viremia/*ETIOLOGY/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

