       Document 0059
 DOCN  M9630059
 TI    Use of BCG in high prevalence areas for HIV.
 DT    9603
 AU    Felten MK; Leichsenring M; Tuberculosis Unit, University of Heidelberg
       Medical School,; Germany.
 SO    Trop Med Parasitol. 1995 Jun;46(2):69-71. Unique Identifier : AIDSLINE
       MED/96131070
 AB    Recommendations state that, where the risk of tuberculosis is high, BCG
       should be administered to infants as early in life as possible, even if
       the mother is known to be HIV-infected. BCG should be withheld from
       individuals with symptomatic HIV infections. However, continuing reports
       from sub-Saharan Africa and elsewhere of BCG complications in
       HIV-infected persons call for a re-assessment of current vaccination
       policies. For HIV-infected infants any benefit of BCG vaccination may be
       marginal because the prognosis is very poor. It is however not possible
       to exclude HIV-infected children from BCG vaccination at birth.
       HIV-uninfected infants born to HIV-infected mothers are at great risk of
       tuberculosis infection, which justifies routine vaccination. BCG rarely
       causes serious complications. Theoretically, persons with asymptomatic
       HIV infection may be at greater risk of complications from BCG vaccines,
       but available data are inconclusive in that respect. To vaccinate
       children with BCG at one year of age does not seem feasible and would
       increase the risk of tuberculosis especially for uninfected infants of
       HIV seropositive mothers. Available data seem to indicate that routine
       vaccination of newborns is indeed safe, even in areas with high
       prevalence of HIV infection.
 DE    Africa South of the Sahara/EPIDEMIOLOGY  AIDS-Related Opportunistic
       Infections/*PREVENTION & CONTROL  *BCG Vaccine/ADVERSE EFFECTS  Disease
       Transmission, Vertical  Female  Human  HIV
       Infections/EPIDEMIOLOGY/*PREVENTION & CONTROL/TRANSMISSION  *HIV
       Seroprevalence  Infant  Infant, Newborn  Pregnancy  Pregnancy
       Complications, Infectious/VIROLOGY  Risk Factors  Support, Non-U.S.
       Gov't  Tuberculosis, Pulmonary/EPIDEMIOLOGY/ETIOLOGY/*PREVENTION &
       CONTROL  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

