       Document 0054
 DOCN  M9630054
 TI    Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E
       production.
 DT    9603
 AU    Yoshimoto T; Bendelac A; Watson C; Hu-Li J; Paul WE; Laboratory of
       Immunology, National Institute of Allergy and; Infectious Diseases,
       National Institute of Health, Bethesda, MD; 20892, USA.
 SO    Science. 1995 Dec 15;270(5243):1845-7. Unique Identifier : AIDSLINE
       MED/96106416
 AB    Immune responses dominated by interleukin-4 (IL-4)-producing T helper
       type 2 (TH2) cells or by interferon gamma (IFN-gamma)-producing T helper
       type 1 (TH1) cells express distinctive protection against infection with
       different pathogens. Interleukin-4 promotes the differentiation of naive
       CD4+ T cells into IL-4 producers and suppresses their development into
       IFN-gamma producers. CD1-specific splenic CD4+NK1.1+ T cells, a
       numerically minor population, produced IL-4 promptly on in vivo
       stimulation. This T cell population was essential for the induction of
       IL-4-producing cells and for switching to immunoglobulin E, an
       IL-4-dependent event, in response to injection of antibodies to
       immunoglobulin D.
 DE    Animal  Cells, Cultured  CD4-Positive T-Lymphocytes/*IMMUNOLOGY
       IgE/*BIOSYNTHESIS  Interleukin-4/BIOSYNTHESIS  Killer Cells, Natural
       Mice  Mice, Inbred BALB C  Mice, Inbred C57BL  Spleen/CYTOLOGY  Thymus
       Gland/CYTOLOGY  Th2 Cells/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

