       Document 0037
 DOCN  M9630037
 TI    [The presence of HIV DNA in the neutrophils of persons infected with the
       human immunodeficiency virus and the clinical parallels of this
       phenomenon]
 DT    9603
 AU    Gabrilovich DI; Vasilev VB; Nosikov VV; Serebrovskaia LV; Shepeleva GK;
       Ivanova LA; Pokrovskii VV
 SO    Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct;(5):52-5. Unique
       Identifier : AIDSLINE MED/96093392
 AB    Relationships between some clinical data and the detection of human
       immunodeficiency virus (HIV) DNA in polymorphonuclear neutrophils (PMN)
       of 37 HIV-infected persons were studied. HIV DNA was determined with the
       use of polymerase chain reaction. The level of HIV DNA in PMN,
       sufficient for determination, was mostly detected in persons with
       clinical manifestations of HIV infection and less frequently in
       asymptomatic patients (46.7% and 18.2% respectively, p < 0.05). The
       significant relationship between the presence of HIV DNA in NP and a
       decrease in the CD4/CD8 ratio, as well as an increase in the level of
       immunoglobulins in the blood serum, has been established. The presence
       of HIV DNA in PMN was positively related to the decrease of the
       functional activity of these cells and the level of PMN in peripheral
       blood. The infection of PMN with HIV may be one of important mechanisms
       of their damage in HIV infection.
 DE    Adult  Cell Separation  Comparative Study  CD4-CD8 Ratio  DNA,
       Viral/*BLOOD/ISOLATION & PURIF  English Abstract  Female  Human  HIV
       Infections/*BLOOD/VIROLOGY  HIV-1/*GENETICS  Male  Neutrophils/*VIROLOGY
       Nitroblue Tetrazolium/DIAGNOSTIC USE  Phagocytosis  Polymerase Chain
       Reaction/METHODS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

