       Document 0036
 DOCN  M9630036
 TI    [The effect of the blood serum factors of HIV-infected persons on the
       functional activity of the neutrophils in healthy donors]
 DT    9603
 AU    Gabrilovich DI; Ivanova LA; Shepeleva GK; Serebrovskaia LV; Buravtsova
       EV; Pokrovskii VV
 SO    Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct;(5):56-60. Unique
       Identifier : AIDSLINE MED/96093393
 AB    The influence of 64 blood serum samples from HIV-infected patients at
       different stages of the infection on the functional activity of
       polymorphonuclear neutrophils (PMN) of 9 healthy donors was studied. In
       this study an increase in the production of oxygen radicals by PMN of
       the donors was revealed (in the chemiluminescence test), positive
       correlations between this increase and stages of HIV infection were
       followed. The presence of HIV-positive serum in the incubation medium
       led to the inhibition of phagocytosis and produced almost no changes in
       the capacity of PMN for its completion. A decrease in phagocytosis
       correlated with the level of complement and did not depend on other
       serum factors; on the contrary, an increase in chemiluminescence was not
       linked with the levels of complement, but had correlative relationships
       with the levels of anti-HIV antibodies and circulating immune complexes.
 DE    Adolescence  Adult  *Blood Donors  Chemiluminescence  Comparative Study
       English Abstract  Female  Free Radicals/BLOOD  Human  HIV
       Infections/*BLOOD  *HIV-1  Male  Neutrophil Activation/*PHYSIOLOGY
       Neutrophils/METABOLISM  Oxygen/BLOOD  Phagocytosis  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

