       Document 0009
 DOCN  M9630009
 TI    Increased incidence of central venous catheter-related infections in
       bone marrow transplant patients.
 DT    9603
 AU    Keung YK; Watkins K; Chen SC; Groshen S; Levine AM; Douer D; Department
       of Medicine, University of Southern California, Los; Angeles, USA.
 SO    Am J Clin Oncol. 1995 Dec;18(6):469-74. Unique Identifier : AIDSLINE
       MED/96105310
 AB    In view of an apparent increase of central venous catheter-related
       infections among our bone marrow transplant (BMT) patients, a
       retrospective study of infectious complications of central venous
       catheters was conducted. During 1992, 147 central venous catheters were
       placed in 133 patients. The overall infection rate of all catheters was
       3.3 per thousand catheter-days (bacteremia 1.8, site infection 1.5).
       Patients scheduled for BMT had the highest infection rate of 11.5
       (bacteremia 6.7, site infection 4.8). HIV patients had an infection rate
       of 6.6 per thousand catheter-days (bacteremia 3.8 and site infection
       2.8) and patients with other diagnoses had a rate of 2.4 (bacteremia 1.3
       and site infection 1.1). The difference of infection risk among the
       three groups is statistically significant (logrank p < .0001). In
       analyzing the 11 BMT patients more carefully, 14 catheters were placed.
       Of these, 9 catheters were removed, 8 (89%) of which were secondary to
       infection. Multivariate analysis showed that patients under 50 and BMT
       patients were more likely to develop catheter-related infection. While
       the cause of this complication is not known at present, the possible
       association with PBSC harvest is of much concern.
 DE    Adult  Age Factors  Aged  Aged, 80 and over
       Bacteremia/EPIDEMIOLOGY/ETIOLOGY  *Bone Marrow Transplantation
       Catheterization, Central Venous/*ADVERSE EFFECTS  Female  Human
       Incidence  Infection/EPIDEMIOLOGY/*ETIOLOGY  Male  Middle Age
       Multivariate Analysis  Proportional Hazards Models  Retrospective
       Studies  Risk Factors  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

