       Document 0008
 DOCN  M9630008
 TI    High frequency of CD45RO expression in AIDS-related B-cell non-Hodgkin's
       lymphomas.
 DT    9603
 AU    Gloghini A; De Paoli P; Gaidano G; Franceschi S; Carbone A; Division of
       Pathology, Istituto Nazionale di Ricovero e Cura a; Carattere
       Scientifico, Aviano, Italy.
 SO    Am J Clin Pathol. 1995 Dec;104(6):680-8. Unique Identifier : AIDSLINE
       MED/96105176
 AB    Although immunophenotypic abnormalities have been reported in B-cell
       non-Hodgkin's lymphomas (NHLs) occurring in the general population,
       there are no extensive studies on such abnormalities in AIDS-related
       B-cell NHLs. Reactivity of CD45RO/UCHL1 and expression of other T-cell
       associated antigens (CD43, OPD4, CD3, CD5, EMA) were examined by
       immunohistochemistry in 66 diffuse aggressive AIDS-related B-cell NHLs
       and in 296 AIDS-unrelated B-cell NHLs of similar morphology analyzed in
       the same institution. EBER in situ hybridization studies were also
       carried out in 57 of the 66 AIDS-related B-cell NHLs investigated.
       CD45RO/UCHL1 was expressed in 27% of AIDS-related B-cell NHLs, but only
       in 8% of diffuse aggressive AIDS-unrelated B-cell NHLs. The difference
       was highly significant (P < .001) overall and, within the Working
       Formulation subtypes, especially marked among small noncleaved cell
       (SNCC) lymphomas. Conversely, the reactivity of other T-cell associated
       antigens seemed to be very similar in AIDS-related and AIDS-unrelated
       NHLs. However, for CD43, a significantly lower number of positive cases
       was found in AIDS-related NHLs among SNCC lymphomas. Among AIDS-related
       B-cell NHLs, the highest frequency of CD45RO/UCHL1 expression was found
       in the immunoblastic subset with plasmacytoid differentiation. In the
       latter CD45RO/UCHL1 preferentially associated with EMA expression and
       EBV infection of the tumor clone, but not with CD45RA. The present
       finding of an excess of CD45RO/UCHL1 expression in AIDS-related B-cell
       lymphomas may reflect the preferential expansion of CD45RO expressing
       B-cell clones with putative autoreactive potential, as suggested by the
       expansion of CD45RO expressing B-cells in autoimmune disorders.
 DE    Antibodies, Monoclonal  Antigens, CD45/*ANALYSIS  Comparative Study
       Human  Lymphoma, AIDS-Related/*IMMUNOLOGY/PATHOLOGY  Lymphoma,
       Non-Hodgkin's/*IMMUNOLOGY/PATHOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

