       Document 0006
 DOCN  M9630006
 TI    Somatic symptoms and HIV infection: relationship to depressive symptoms
       and indicators of HIV disease.
 DT    9603
 AU    Perkins DO; Leserman J; Stern RA; Baum SF; Liao D; Golden RN; Evans DL;
       Department of Psychiatry, University of North Carolina School of;
       Medicine, Chapel Hill 27599-7160, USA.
 SO    Am J Psychiatry. 1995 Dec;152(12):1776-81. Unique Identifier : AIDSLINE
       MED/96080014
 AB    OBJECTIVE: This study examined the relationship of the somatic symptoms
       fatigue and insomnia with indicators of both psychiatric disturbance and
       HIV disease severity. METHOD: Study participants were 98 asymptomatic
       HIV-infected and 71 uninfected homosexual men; 82 HIV-infected and 64
       uninfected men had 6-month follow-up examinations. Scales from the
       self-reported Profile of Mood States measured fatigue and dysphoric
       mood. Major depression diagnosis was determined by the Structured
       Clinical Interview for DSM-III-R. Selected items from the Hamilton
       depression and anxiety scales measured insomnia and other symptoms of
       depression. Performance on a battery of standardized tests determined
       neuropsychological function ratings. RESULTS: At study entry, complaints
       of fatigue and insomnia were associated with dysphoric mood, major
       depression, and other non-HIV-related symptoms of major depression but
       not with CD4 cell counts or neuropsychological functioning. Increases in
       levels of fatigue and insomnia over the 6-month follow-up period were
       associated with increases in non-HIV-related symptoms of depression and
       in severity of dysphoric mood. Increases in fatigue were also associated
       with decrements in motor functioning. Otherwise, fatigue or insomnia
       were not associated with HIV disease progression. CONCLUSIONS: These
       findings suggest that complaints of fatigue and insomnia in otherwise
       asymptomatic HIV-infected patients are likely to be related to
       psychological disturbances and possibly major depression, which can be
       treated. HIV-infected patients who complain of fatigue or insomnia
       should routinely be assessed for major depression.
 DE    Adult  Comorbidity  CD4 Lymphocyte Count  Depressive
       Disorder/*DIAGNOSIS/EPIDEMIOLOGY  Fatigue/*DIAGNOSIS/EPIDEMIOLOGY
       Follow-Up Studies  Homosexuality, Male/PSYCHOLOGY  Human  HIV
       Infections/*DIAGNOSIS/PSYCHOLOGY  Insomnia/*DIAGNOSIS/EPIDEMIOLOGY  Male
       Neuropsychological Tests  Personality Inventory  Prevalence  Psychiatric
       Status Rating Scales  Regression Analysis  Severity of Illness Index
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

