       Document 1081
 DOCN  M9621081
 TI    Serum reactivity against an immunoregulatory sequence of HIV p24 in
       HIV-1-infected subjects.
 DT    9602
 AU    Cordiali Fei P; Solmone M; Prignano G; Pugliese O; Viora M; Luzzati A;
       Ameglio F; Laboratory of Clinical Pathology, Istituto San Gallicano,
       Rome,; Italy.
 SO    Viral Immunol. 1994;7(4):199-203. Unique Identifier : AIDSLINE
       MED/96100714
 AB    The aim of this study was to assess the antibody reactivity in
       HIV-infected subjects against an HIV-1 p24 sequence, p226 (aa226-237),
       including a seven amino acid epitope showing immunosuppressive activity
       in vitro and to evaluate the relationship between anti-peptide antibody
       levels and disease progression. Sera of HIV-infected subjects, at
       different stages of disease, were compared to control sera in a
       retrospective evaluation. Recombinant HIV-1 p24 and p24- and
       control-peptides were used in an enzyme immunoassay as targets for
       antibodies present in the sera. Antibodies directed against the whole
       p24 protein and its peptides were found in all the sera studied but at
       different levels. The anti-p226 reactivity was not significantly
       different at different clinical stages. Nevertheless, it was inversely
       correlated to the reactivity directed against the whole protein, that
       was lower in subjects characterized by low CD4 cell numbers.
 DE    Amino Acid Sequence  CD4 Lymphocyte Count  Human  HIV
       Antibodies/BIOSYNTHESIS/*BLOOD  HIV Core Protein
       p24/*IMMUNOLOGY/PHARMACOLOGY  HIV Infections/*BLOOD/IMMUNOLOGY
       HIV-1/IMMUNOLOGY  Immunosuppressive Agents/*PHARMACOLOGY  Lymphocyte
       Transformation  Molecular Sequence Data  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

