       Document 1068
 DOCN  M9621068
 TI    Campylobacter infections in HIV-infected patients: clinical and
       bacteriological features.
 DT    9602
 AU    Molina J; Casin I; Hausfater P; Giretti E; Welker Y; Decazes J; Garrait
       V; Lagrange P; Modai J; Infectious Disease Department, Saint-Louis
       Hospital, Paris,; France.
 SO    AIDS. 1995 Aug;9(8):881-5. Unique Identifier : AIDSLINE MED/96014961
 AB    OBJECTIVE: To study the clinical and bacteriological features of
       Campylobacter infections in HIV-infected patients. DESIGN: A
       retrospective analysis (1989-1992), followed by a prospective analysis
       (1992-1994). SETTING: Hospital HIV inpatient unit. PATIENTS AND METHODS:
       All patients with Campylobacter spp. identified by the laboratory of
       microbiology at Saint-Louis Hospital, Paris were studied, and their
       clinical features as well as their response to therapy recorded.
       RESULTS: During the study period, Campylobacter infection was documented
       in 38 HIV-infected patients, 76% of whom had AIDS. Campylobacter spp.
       was isolated from stools in 36 cases and from blood cultures in four
       cases. Species identification yielded C. jejuni (84%) and C. coli (16%).
       High-level resistance to quinolones was frequently observed (21%), but
       resistance to erythromycin (3%) and tetracycline (5%) was rare.
       Diarrhoea, fever and abdominal pain were the main clinical features of
       infection. Other intestinal pathogens were found in 42% of patients.
       Most patients had an acute illness with rapid resolution under
       appropriate antimicrobial therapy. However, eight patients (21%),
       experienced chronic diarrhoea with persistent isolation of Campylobacter
       and in vivo selection of resistant strains, requiring multiple courses
       of antibiotics. CONCLUSIONS: Campylobacter usually cause acute diarrhoea
       in patients with HIV infection. Antimicrobial therapy should be guided
       on in vitro susceptibility testing because of the prevalence of
       antibiotic resistance. Despite appropriate therapy, some patients will
       present with prolonged diarrhoea and in vivo selection of multiresistant
       isolates.
 DE    Adult  Antibiotics/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/DRUG THERAPY/  MICROBIOLOGY  *Campylobacter
       coli/DRUG EFFECTS/ISOLATION & PURIF  *Campylobacter jejuni/DRUG
       EFFECTS/ISOLATION & PURIF  Case Report  Diarrhea/COMPLICATIONS/DRUG
       THERAPY/MICROBIOLOGY  Drug Resistance, Microbial  Feces/VIROLOGY  Female
       Human  Male  Middle Age  Prospective Studies  Retrospective Studies
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

