       Document 1067
 DOCN  M9621067
 TI    Micronutrient levels in HIV-1-infected children.
 DT    9602
 AU    Periquet BA; Jammes NM; Lambert WE; Tricoire J; Moussa MM; Garcia J;
       Ghisolfi J; Thouvenot J; Purpan Hospital, Toulouse, France.
 SO    AIDS. 1995 Aug;9(8):887-93. Unique Identifier : AIDSLINE MED/96014962
 AB    OBJECTIVE: Micronutrients (zinc, copper, selenium, vitamin A, E, and
       carotenoids) are essential for the integrity of host defences. This
       study was designed to determine the prevalence of abnormalities of the
       micronutrient levels in HIV-1-seropositive children. DESIGN: Prospective
       study. SETTING: The study was performed on HIV-1-infected children at
       the Paediatric Haematology and Oncology Unit of Toulouse Hospital,
       France. PATIENTS: Twenty-one children, suffering from HIV-1 infection
       and 21 control subjects of similar age (2-9 years) were included in the
       study. In the HIV-1-infected children, two subgroups were considered
       according to stage (non-AIDS or AIDS), based on the Centers for Disease
       Control and Prevention 1987 criteria. RESULTS: The first statistically
       significant deficiencies occurred at non-AIDS stage and were confirmed
       at AIDS stage: P < 0.05 for lycopene, retinol, tocopherol and P < 0.001
       for transthyretin and serum albumin. Levels of copper (40%) and
       long-chain polyunsaturated fatty acids (21%) were higher in the non-AIDS
       group than the controls. CONCLUSION: Biological impairing of the
       micronutrient levels was observed in the non-AIDS stage without clinical
       sign. This information is useful in delineating eventual and well
       considered nutritional intervention strategies that may improve the
       clinical status of HIV-1-infected children and perhaps alter the course
       of their disease.
 DE    Carotene/BLOOD/DEFICIENCY  Case-Control Studies  Child  Child, Preschool
       Copper/BLOOD  Erythrocytes/METABOLISM  Fatty Acids, Unsaturated/BLOOD
       Female  Human  HIV Infections/*BLOOD/CLASSIFICATION/COMPLICATIONS
       *HIV-1  Male  Micronutrients/*METABOLISM  Nutritional Status
       Prealbumin/DEFICIENCY/METABOLISM  Prospective Studies  Serum
       Albumin/DEFICIENCY  Support, Non-U.S. Gov't  Vitamin A/BLOOD  Vitamin A
       Deficiency/BLOOD/COMPLICATIONS  Vitamin E/BLOOD  Vitamin E
       Deficiency/BLOOD/COMPLICATIONS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

