       Document 1064
 DOCN  M9621064
 TI    HIV infection and invasive cervical carcinoma in an Italian population:
       the need for closer screening programmes in seropositive patients.
 DT    9602
 AU    Zanetta G; Maneo A; Colombo A; Ragusa A; Gabriele A; Placa F; Mangioni
       C; Department of Obstetrics and Gynaecology, S. Gerardo Hospital,;
       University of Milan, Monza, Italy.
 SO    AIDS. 1995 Aug;9(8):909-12. Unique Identifier : AIDSLINE MED/96014965
 AB    OBJECTIVE: To evaluate in an Italian population the prevalence,
       characteristics at first diagnosis and outcome of HIV-seropositive
       individuals with cervical carcinoma referred to a tertiary-care
       institution. DESIGN: A retrospective evaluation of all patients referred
       for invasive cervical carcinoma from 1991 to 1994. SETTING: The
       departments of obstetrics and gynaecology, and radiotherapy at San
       Gerardo Hospital, University of Milan, Italy. PATIENTS: A total of 340
       women were treated over a 3-year period (186 aged < 50 years). Six
       patients were found to be HIV-seropositive. INTERVENTIONS: Seropositive
       patients were treated according to current institutional protocols,
       irrespective of HIV status. Four underwent radiotherapy and two radical
       hysterectomy as primary treatment. RESULTS: Although five
       HIV-seropositive patients were known to be infected 13-81 months before
       diagnosis of cervical cancer, none had received a PAP smear in the last
       year and only one in the last 2 years. HIV patients were younger than
       general population (P = 0.02), with a significant history of intravenous
       drug use (P = 0.000001) and with more advanced disease (P = 0.04). Two
       HIV-positive patients also received polychemotherapy (one adjuvant and
       one salvage treatment) and both completed the planned treatment. Within
       24 months two patients had died of cancer and one of AIDS; one is alive
       with AIDS and cancer and two are free of disease. CONCLUSIONS: This
       study confirms that in a southern European population, HIV-seropositive
       women present to tertiary-care institutions with more advanced disease
       and have a poorer prognosis than the general population. Strict
       screening programs for cervical dysplasia and cancer are warranted for
       HIV-seropositive patients.
 DE    Adult  Cervix Neoplasms/*COMPLICATIONS/EPIDEMIOLOGY/PREVENTION & CONTROL
       Female  Human  HIV Infections/*COMPLICATIONS/EPIDEMIOLOGY
       Italy/EPIDEMIOLOGY  Mass Screening  Middle Age  Prognosis  Retrospective
       Studies  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

