       Document 1029
 DOCN  M9621029
 TI    Extraordinary high rate of HTLV type II seropositivity in intravenous
       drug abusers in south Vietnam.
 DT    9602
 AU    Fukushima Y; Takahashi H; Hall WW; Nakasone T; Nakata S; Song P; Dinh
       Duc D; Hien B; Nguyen XQ; Ngoc Trinh T; et al; Laboratory of Immunology,
       AIDS Research Center, National; Institute of Health, Tokyo, Japan.
 SO    AIDS Res Hum Retroviruses. 1995 May;11(5):637-45. Unique Identifier :
       AIDSLINE MED/96093899
 AB    Serum specimens (n = 1899) were assayed for infections with HTLV-I,
       HTLV-II, and HIV-1 in seven classified groups of normal healthy
       controls, children, pregnant women, prostitutes, intravenous drug
       abusers, patients under going hemodialysis, and hemophiliacs in South
       and North Vietnam. Surprisingly, 125 of 954 samples from South Vietnam
       exhibited seropositivity for HTLV-II and 119 of these belonged to the
       group of IVDAs (n = 200). The remaining six positives were a healthy
       control, a prostitute, two children, and two patients under going
       hemodialysis. Two IVDAs who were seropositive for HTLV-I and 10 of 15
       seropositives for HIV-1 were also positive for HTLV-II in this
       population. In contrast, no seropositives to any of the viruses were
       detected in the North Vietnamese samples (0 of 945). The
       HTLV-II-seropositive IVDAs exhibited increased seropositivity with age
       compared with HIV-1 seropositivity in the population, and there was no
       statistical relation between seropositivity for HTLV-II and HIV-1. The
       HTLV-IIs in South Vietnam IVDAs appeared, by subtype-specific peptide
       ELISA, to be a mixture of both subtypes a and b, with subtype a
       predominant. It seems possible that HTLV-II may have been introduced
       into this population from IVDAs from the United States during the
       Vietnam conflict, but in a period prior to, or early in, the
       introduction of HIV-1 to IVDAs.
 DE    Adult  Amino Acid Sequence  Child  Female  Human  HIV
       Seropositivity/BLOOD/VIROLOGY  HIV-1/ISOLATION & PURIF  HTLV-I/ISOLATION
       & PURIF  HTLV-II/CLASSIFICATION/ISOLATION & PURIF  HTLV-II
       Infections/*COMPLICATIONS/EPIDEMIOLOGY/VIROLOGY  Male  Molecular
       Sequence Data  Pregnancy  Seroepidemiologic Methods  Substance Abuse,
       Intravenous/*COMPLICATIONS/VIROLOGY  Support, Non-U.S. Gov't
       Vietnam/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

