       Document 1013
 DOCN  M9621013
 TI    Animal models recapitulate aspects of HIV/CNS disease.
 DT    9602
 AU    Vitkovic L; Stover E; Koslow SH; Division of Neuroscience and Behavioral
       Science, National; Institute of Mental Health, National Institutes of
       Health,; Rockville, Maryland 20857, USA.
 SO    AIDS Res Hum Retroviruses. 1995 Jun;11(6):753-9. Unique Identifier :
       AIDSLINE MED/96078237
 AB    Neurobehavioral and pathological data indicate that the central nervous
       system (CNS) becomes infected with HIV-1 soon after the virus enters the
       body. However, neuropathogenesis of HIV-1 infection is difficult to
       investigate because the brain parenchyma is not accessible to sampling
       during the course of AIDS. The second compartment of the CNS,
       cerebrospinal fluid (CSF), is accessible to sampling but how changes in
       the CSF relate to the changes in the parenchyma is poorly understood.
       Thus, knowledge of the neuropathogenesis of HIV-1 infection
       predominantly stems from either postmortem or in vitro studies. This
       raises the need for animal models of HIV infection of the CNS. Such
       models have been developed and are briefly reviewed here. The models
       faithfully recapitulate some aspects of the HIV/CNS disease. Appropriate
       neuropathological changes and neurobehavioral dysfunction (e.g.,
       cognitive and motor deficits) occur in SIV-infected macaques. Central
       sensory electrophysiological changes and sleep disturbances occur in
       FIV-infected cats. Infection of the brain and behavioral changes
       comparable to some of the changes seen in humans occur in mice infected
       with a mixture of murine leukemia viruses. Genetically immunodeficient
       mice (e.g., SCID) accept HIV-infected human organs and or cell grafts.
       Evidence summarized here indicates that these HuSCID animals undergo
       neuropathological changes similar to those observed in brains of
       individuals who died with AIDS. Thus, presently available animal models
       provide an opportunity to investigate HIV/CNS disease, and to develop
       and test therapeutic interventions to prevent or cure the disease.
 DE    Animal  *AIDS Dementia Complex  *Central Nervous System Diseases
       *Disease Models, Animal  Feline Acquired Immunodeficiency Syndrome
       Human  *HIV Infections  *HIV-1  *Lentivirus Infections  Mice  Mice, SCID
       Simian Acquired Immunodeficiency Syndrome  MEETING REPORT  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

