       Document 0991
 DOCN  M9620991
 TI    Association of changes in monocyte antigen presentation and cytokine
       production in haemophilic boys with treatment and blood-borne virus
       infection.
 DT    9602
 AU    Pasi KJ; Evans JA; Wadhwa M; Thorpe R; Hill FG; Children's Hospital,
       Ladywood, Birmingham.
 SO    Br J Haematol. 1995 Sep;91(1):191-6. Unique Identifier : AIDSLINE
       MED/96070648
 AB    Aspects of monocyte function (antigen presentation and cytokine
       production (e.g. IL-1, IL-6) have been studied in a normal control
       population and three groups of haemophilic boys: group 1 HIV and HCV
       seronegative and treated only with a single heat-treated factor VIII
       (FVIII) concentrate; group 2 HIV seronegative but HCV seropositive;
       group 3 all HIV and HCV seropositive. Groups 2 and 3 have been
       previously treated with unheated and heated FVIII concentrate. Group 1
       boys (HIV/HCV uninfected) showed no significant reduction in monocyte
       antigen presentation function nor IL-1 or IL-6 production when compared
       with a control population. Group 2 boys (HCV infected) showed a reduced
       monocyte antigen presentation activity (P < 0.05), but no significant
       reduction in IL-1 or IL-6 production. Group 3 boys (HIV and HCV
       infected) showed a significantly reduced monocyte antigen presentation
       activity (P < 0.001) and an impairment of IL-1 and IL-6 production (P <
       0.05). A significant reduction of IL-1 and IL-6 production was only seen
       in the HIV and HCV infected haemophilic boys, implicating HIV as an
       aetiological agent. In contrast, reduced monocyte antigen presentation
       activity was seen in haemophilic boys with both HIV and HCV infection or
       HCV alone. The HIV and HCV seronegative boys had normal antigen
       presentation. The absence of immune modulation in haemophilic boys that
       have not acquired HIV and HCV infection suggests that chronic
       blood-borne virus infections as contributory to immune modulation seen
       in haemophiliacs with virus infections.
 DE    Adolescence  Antigen Presentation  Child  Child, Preschool  Factor
       VIII/THERAPEUTIC USE  Hemophilia/DRUG THERAPY/*IMMUNOLOGY  Hepatitis
       C/*IMMUNOLOGY  Human  HIV Infections/*IMMUNOLOGY
       Interleukin-1/BIOSYNTHESIS  Interleukin-6/BIOSYNTHESIS
       Lymphocytes/IMMUNOLOGY  Male  Monocytes/*IMMUNOLOGY  Prospective Studies
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

