       Document 0990
 DOCN  M9620990
 TI    Evidence for the aetiological role of blood-borne virus infections in
       causing reduced lectin-induced T-cell proliferation in haemophilic boys.
 DT    9602
 AU    Evans JA; Pasi KJ; Hill FG; Department of Haematology, Children's
       Hospital, Ladywood,; Birmingham.
 SO    Br J Haematol. 1995 Sep;91(1):197-202. Unique Identifier : AIDSLINE
       MED/96070649
 AB    T-lymphocyte function, as expressed by polyclonal proliferation to
       lectin mitogens phytohaemagglutinin and concanavalin A, has been studied
       in a normal control population and three groups of haemophilic boys:
       group 1, HIV and HCV seronegative and treated only with a single
       heat-treated factor VIII (FVIII) concentrate; group 2, HIV seronegative
       but HCV seropositive; group 3, all HIV and HCV seropositive. Groups 2
       and 3 have been previously treated with unheated and heated FVIII
       concentrate. Group 1 boys (HIV/HCV uninfected) showed no significant
       reduction in lymphocyte proliferation when compared with a control
       population. Group 2 and 3 boys showed an impaired response to these
       mitogens compared to group 1 boys and the control group. There was no
       relationship between FVIII concentrate received and proliferative
       response. The absence of immune modulation in haemophilic boys who have
       not acquired HIV and HCV infection implicates chronic blood-borne virus
       infections as the major contributory factors to impaired lymphocyte
       proliferative responses seen in haemophiliacs treated with large-pool
       concentrates. The presence of virus infections, such as HCV, may account
       for similar lymphocyte function abnormalities observed in previously
       described cohorts.
 DE    Adolescence  Child  Child, Preschool  Concanavalin A/IMMUNOLOGY  Factor
       VIII/THERAPEUTIC USE  Follow-Up Studies  Hemophilia/DRUG
       THERAPY/*IMMUNOLOGY  Hepatitis C/*IMMUNOLOGY  Human  HIV
       Seropositivity/*IMMUNOLOGY  *Immune Tolerance  Lymphocyte Transformation
       Male  Phytohemagglutinins/IMMUNOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

