       Document 0956
 DOCN  M9620956
 TI    Disseminated microsporidiosis due to Septata intestinalis in nine
       patients infected with the human immunodeficiency virus: response to
       therapy with albendazole.
 DT    9602
 AU    Dore GJ; Marriott DJ; Hing MC; Harkness JL; Field AS; Department of
       Microbiology, St. Vincent's Hospital, Sydney,; Australia.
 SO    Clin Infect Dis. 1995 Jul;21(1):70-6. Unique Identifier : AIDSLINE
       MED/96065615
 AB    Disseminated microsporidiosis due to the newly described species Septata
       intestinalis in nine patients infected with human immunodeficiency virus
       is described. All patients were male homosexuals; the mean age was 41
       years (range, 35-58 years). They were all severely immunocompromised,
       with a mean CD4 lymphocyte count of 15/mm3 (range, 0-32/mm3). Infection
       by S. intestinalis was seen in duodenal biopsy specimens from all
       patients, and dissemination was demonstrated by the presence of
       microsporidial spores in urine (9 of 9 patients), sinonasal secretions
       and/or nasal mucosal biopsy specimens (6 of 6), and sputum (6 of 6).
       Seven patients were treated with albendazole (400 mg twice daily),
       resulting in significant dissipation or complete resolution of diarrhea
       for six patients and abatement of symptoms for the six patients with
       chronic rhinosinusitis. There was a parallel parasitological response,
       with clearance of S. intestinalis infection from almost all sites.
 DE    Adult  Albendazole/*THERAPEUTIC USE  Animal  Anthelmintics/*THERAPEUTIC
       USE  AIDS-Related Opportunistic Infections/DRUG THERAPY/*PARASITOLOGY
       Duodenum/PARASITOLOGY/ULTRASTRUCTURE  Feces/PARASITOLOGY  Human
       Immunocompromised Host  Intestinal Diseases, Parasitic/DRUG
       THERAPY/*PATHOLOGY  Male  Microspora Infections/DRUG THERAPY/*PATHOLOGY
       Microsporida/DRUG EFFECTS/*ISOLATION & PURIF/ULTRASTRUCTURE  Middle Age
       Nasal Lavage Fluid/PARASITOLOGY  Sputum/PARASITOLOGY  Urine/PARASITOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

