       Document 0909
 DOCN  M9620909
 TI    Factors associated with progression to AIDS and mortality in a cohort of
       HIV-infected patients with hemophilia followed up since seroconversion.
 DT    9602
 AU    Santagostino E; Gringeri A; Cultraro D; Tradati F; Siracusano L;
       Marinoni A; Mannucci PM; A. Bianchi Bonomi Hemophilia and Thrombosis
       Center, Institute of; Internal Medicine, IRCCS Maggiore Hospital,
       University of Milan,; Italy.
 SO    Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):371-80. Unique Identifier
       : AIDSLINE MED/96059397
 AB    Progression to AIDS and death were evaluated in 112 patients, 84 with
       hemophilia A and 28 with hemophilia B. Seroconversion period and age at
       seroconversion were similar in both groups. 36/112 patients died: 21/84
       with hemophilia A (25%) and 15/28 (54%) with hemophilia B. Mean survival
       time was 11.7 years. The 10-year cumulative survival was 75.8%. It was
       lower in hemophilia B (56.2%) compared to hemophilia A patients (82.4%;
       p = 0.002). 37 patients (33%) developed full-blown AIDS: 26 with
       hemophilia A (31%) and 11 with hemophilia B (39%). Mean AIDS-free
       survival time was 11.4 years. The 10-year cumulative AIDS-free survival
       was 71.2%. It was 74.8% in hemophilia A and 60.3% in hemophilia B
       patients. CD4 counts lower than 200/cmm occurred in 62 patients (56%):
       45 with hemophilia A (54%) and 17 with hemophilia B (63%). The mean time
       to CD4 counts lower than 200 was 9.4 years. Mean survival time in older
       seroconverters (35 year old or more) was shorter than in younger (9.5
       vs. 11.7 years, p < 0.05). Mean CD4 cell counts at seroconversion were
       similar in hemophilia A and B patients and in different age classes at
       seroconversion. CD4 cell counts at seroconversion affected the survival:
       90% seroconverters with CD4 cell counts of 800/cmm or more were alive at
       10 years vs. 60% of seroconverters with CD4 cell counts lower than 800
       (p < 0.05).
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/*ETIOLOGY/
       IMMUNOLOGY/*MORTALITY  Adolescence  Adult  Age Factors  Child  Child,
       Preschool  Christmas Disease/*COMPLICATIONS/DRUG THERAPY/IMMUNOLOGY
       Cohort Studies  CD4 Lymphocyte Count  Disease Progression  Disease-Free
       Survival  Female  Hemophilia/*COMPLICATIONS/DRUG THERAPY/IMMUNOLOGY
       Human  HIV Seropositivity  HIV Seroprevalence  HIV-1/IMMUNOLOGY  Italy
       Male  Middle Age  Survival Analysis  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

