       Document 0903
 DOCN  M9620903
 TI    Impairment of circulating lactoferrin in HIV-1 infection.
 DT    9602
 AU    Defer MC; Dugas B; Picard O; Damais C; U313 INSERM, Centre de Recherche
       des Cordeliers, Paris, France.
 SO    Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):417-21. Unique Identifier
       : AIDSLINE MED/96059403
 AB    Levels of plasma lactoferrin are decreased in HIV-1-infected patients in
       relation to the progression of the disease. Plasma lactoferrin
       concentrations were determined using a specific and sensitive enzyme
       immunoassay. 97 plasma were studied (22 asymptomatic, 45 symptomatic
       patients compared to 30 healthy controls) and the results showed a
       highly significant decrease (p < 0.001) of the level of lactoferrin in
       HIV-1-infected patients (respectively 2.79 +/- 1.2 and 0.68 +/- 0.22
       micrograms/ml) compared to controls (4.37 +/- 0.83 micrograms/ml). Since
       it is well established that plasma lactoferrin level could be influenced
       by the number of neutrophils, the experiments were reproduced in
       neutropenic patients who represent 10% of recruitment (6 among 45
       symptomatic patients). The plasma from neutropenic symptomatic patients
       (neutrophils < or = 1,300/mm3) showed their mean lactoferrin level at
       0.36 micrograms/ml still far above the normal values. In view of the
       different reported biological effects of lactoferrin that are of great
       importance in the non-specific defences, the real biological place of
       the lack of such a molecule could be one important component of the
       multifactorial nature of HIV-1 infection.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD  AIDS-Related Complex/*BLOOD
       Comparative Study  CD4 Lymphocyte Count  Disease Progression
       Enzyme-Linked Immunosorbent Assay  Female  Human  HIV
       Seropositivity/DIAGNOSIS  HIV-1/IMMUNOLOGY  Lactoferrin/*BLOOD  Male
       Neutropenia/BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

