       Document 0896
 DOCN  M9620896
 TI    Quality assurance and use of PCR in clinical trials.
 DT    9602
 AU    Reichelderfer PS; Jackson JB; Division of AIDS, National Institute of
       Allergy and Infectious; Diseases, National Institutes of Health,
       Bethesda, Maryland; 20892, USA.
 SO    PCR Methods Appl. 1994 Dec;4(3):S141-9. Unique Identifier : AIDSLINE
       MED/96000014
 AB    Qualitative and quantitative HIV-1 DNA and RNA PCR assays are proving to
       be useful in the diagnosis of HIV-1 infection in infants and in
       assessing the in vivo antiviral activity of new therapies and regimens
       in clinical trials. The use of these standardized commercial assays in
       conjunction with an external quality assurance program has ensured that
       results from different laboratories are comparable. In addition,
       real-time proficiency monitoring has the potential to detect problems
       immediately before patient data are compromised.
 DE    *Clinical Trials  Disease Transmission, Vertical  DNA, Viral/*BLOOD
       Female  Guidelines  Human  HIV Infections/BLOOD/*DIAGNOSIS/TRANSMISSION
       HIV-1/GENETICS/*ISOLATION & PURIF  Infant, Newborn  Lymphocytes/VIROLOGY
       Polymerase Chain Reaction/*STANDARDS  Pregnancy  Pregnancy
       Complications, Infectious/VIROLOGY  Quality Control  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

