       Document 0885
 DOCN  M9620885
 TI    Small subunit ribosomal DNA phylogeny of various microsporidia with
       emphasis on AIDS related forms.
 DT    9602
 AU    Baker MD; Vossbrinck CR; Didier ES; Maddox JV; Shadduck JA; Department
       of Entomology, University of Illinois, Urbana 61801,; USA.
 SO    J Eukaryot Microbiol. 1995 Sep-Oct;42(5):564-70. Unique Identifier :
       AIDSLINE GENBANK/M38637
 AB    Phylogenetic analysis of the small subunit ribosomal DNA of a broad
       range of representative microsporidia including five species from humans
       (Enterocytozoon bieneusi, Nosema corneum, Septata intestinalis,
       Encephalitozoon hellem and Encephalitozoon cuniculi), reveals that human
       microsporidia are polyphyletic in origin. Septata intestinalis and E.
       hellem are very similar to the mammalian parasite E. cuniculi. Based on
       the results of our phylogenetic analysis, we suggest that S.
       intestinalis be designated Encephalitozoon intestinalis. Furthermore,
       analysis of our data indicates that N. corneum is much more closely
       related to the insect parasite Endoreticulatus schubergi than it is to
       other Nosema species. This finding is supported by recent studies which
       have shown a similarity between E. schubergi and N. corneum based on the
       origin and development of the parasitophorous vacuole. Thus these
       opportunistic microsporidian parasites can originate from hosts closely
       or distantly related to humans. Finally, the phylogeny based on small
       subunit ribosomal DNA sequences is highly inconsistent with traditional
       classifications based on morphological characters. Many of the important
       morphological characters (diplokaryon, sporophorous vesicle, and
       meiosis) appear to have multiple-origins.
 DE    Animal  AIDS-Related Opportunistic Infections/*PARASITOLOGY  Base
       Sequence  DNA, Protozoan/*GENETICS  DNA, Ribosomal/*GENETICS  Human
       Microspora Infections/PARASITOLOGY
       Microsporida/CLASSIFICATION/*GENETICS  Molecular Sequence Data
       *Phylogeny  Sequence Analysis, DNA  Spores  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

