       Document 0869
 DOCN  M9620869
 TI    GRO alpha and interleukin-8 in Pneumocystis carinii or bacterial
       pneumonia and adult respiratory distress syndrome.
 DT    9602
 AU    Villard J; Dayer-Pastore F; Hamacher J; Aubert JD; Schlegel-Haueter S;
       Nicod LP; Department of Medicine, Hopital Cantonal Universitaire,
       Geneva,; Switzerland.
 SO    Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1549-54. Unique
       Identifier : AIDSLINE MED/96048812
 AB    Polymorphonuclear leukocytes (PMN) are the predominant inflammatory
       cells recruited in acute lung injury. This study compares the
       concentration of interleukin-8 (IL-8) to those of GRO alpha, both of
       which are CXC chemokines, in bronchoalveolar lavage fluid (BALF) in
       three acute pathologic states: bacterial pneumonia (BPN); adult
       respiratory distress syndrome (ARDS); and Pneumocystis carinii pneumonia
       (PCP). Levels of both IL-8 and GRO alpha were below 5 pg/ml in 16
       nonsmoking volunteers who served as controls. Despite more than twice as
       many neutrophils in the BALF of the BPN group (n = 12) than in the group
       with ARDS (n = 13), both groups had similar levels of IL-8, of 569 +/-
       120 pg/ml and 507 +/- 96 pg/ml, respectively. The GRO alpha
       concentrations in the BPN and ARDS patients were respectively 3.3 and
       3.4 times those of IL-8, reaching 1,870 +/- 314 pg/ml for the BPN and
       1,699 +/- 377 for the ARDS patients. In the PCP group (n = 48, 45 human
       immunodeficiency virus [HIV]-positive, 3 HIV-negative), GRO alpha levels
       (897 +/- 172 pg/ml) were sevenfold higher than IL-8 levels (123 +/- 40
       pg/ml). In all pathologic states there was a good correlation between
       GRO alpha and IL-8 (r = 0.53, p = 0.0001). GRO alpha or IL-8 both
       correlate with the absolute neutrophil number/ml when all groups were
       studied together (r = 0.52, p = 0.0001). Only in the PCP and ARDS groups
       did IL-8 correlate with the PMN number.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adolescence  Adult  AIDS-Related Opportunistic Infections/*METABOLISM
       Bronchoalveolar Lavage Fluid/CHEMISTRY/CYTOLOGY
       Bronchopneumonia/*METABOLISM  Chemokines/*ANALYSIS  Chemotactic
       Factors/*ANALYSIS  Chemotaxis, Leukocyte  Comparative Study  Growth
       Substances/*ANALYSIS  Human  *HIV-1  Interleukin-8/*ANALYSIS  Male
       Neutrophils/PHYSIOLOGY  Pneumonia, Bacterial/*METABOLISM  Pneumonia,
       Pneumocystis carinii/*METABOLISM  Respiratory Distress Syndrome,
       Adult/*METABOLISM  Statistics, Nonparametric  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

