       Document 0846
 DOCN  M9620846
 TI    Comparison of the declines in CD4 counts in HIV-1-seropositive female
       sex workers and women from the general population in Nairobi, Kenya.
 DT    9602
 AU    Bwayo JJ; Nagelkerke NJ; Moses S; Embree J; Ngugi EN; Mwatha A; Kimani
       J; Anzala A; Choudhri S; Achola JO; et al; Department of Medical
       Microbiology, University of Nairobi, Kenya.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):457-61.
       Unique Identifier : AIDSLINE MED/96074279
 AB    Studies from Kenya have reported rapid clinical disease progression
       among HIV-infected professional sex workers. The reasons for this rapid
       decline are unknown. To better understand factors influencing the course
       of disease, HIV-1 disease progression was explored in terms of declines
       in CD4 counts. Two samples from Nairobi, Kenya, were studied, one from a
       cohort of female sex workers and another, as a comparison group, from
       mothers enrolled in an HIV-1 vertical-transmission study. A Markov model
       was used to analyze transitions between HIV-1 disease stages as defined
       by CD4 counts. It appears that sex workers experience a rapid decline in
       CD4 counts, consistent with earlier findings of rapid clinical disease
       progression among individuals in this group. The rate of decline in CD4
       counts among the mothers appears to be lower. It is speculated that
       either intensive exposure to sexually transmitted pathogens or infection
       with several strains of HIV-1 may account for the rapid disease
       progression among female sex workers.
 DE    Adult  Cohort Studies  Comparative Study  CD4 Lymphocyte Count
       CD4-Positive T-Lymphocytes/*IMMUNOLOGY  Disease Progression  Disease
       Transmission, Vertical  Female  Human  HIV Infections/TRANSMISSION  HIV
       Seropositivity/*IMMUNOLOGY/TRANSMISSION  *HIV-1  Kenya  Markov Chains
       *Prostitution  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

