       Document 0844
 DOCN  M9620844
 TI    Evidence for a shift from a type I lymphocyte pattern with HIV disease
       progression. Hemophilia Growth and Development Study.
 DT    9602
 AU    Jason J; Sleeper LA; Donfield SM; Murphy J; Warrier I; Arkin S; Evatt B;
       Division of HIV (AIDS), National Center for Infectious Diseases,;
       Centers for Disease Control and Prevention, Public Health; Service, U.S.
       Department of Health and Human Services, Atlanta,; Georgia 30333, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):471-6.
       Unique Identifier : AIDSLINE MED/96074281
 AB    Whether a shift from a type I (cell mediated) immune profile occurs with
       progressive HIV-related immune dysfunction is a matter of heated debate.
       We analyzed data for 333 HIV antibody-positive (HIV+) and -negative
       (HIV-) hemophilic children/adolescents, to examine whether the
       relationships among immunologic parameters and vaccine-related serology
       supported a shift with advancing HIV infection. In stepwise logistic
       regression analysis of HIV+ children's data, anergy to a panel of
       delayed hypersensitivity skin test antigens was positively associated
       with serum immunoglobulin A (IgA) levels (p = 0.012) and CD8+ cell
       counts (p = 0.021) and negatively associated with CD4+ cell counts (p =
       0.002). Modeling supported anergy as a positive correlate of log IgA
       level (p = 0.046) and CD4+ lymphocyte count as a negative correlate, for
       HIV+ participants only (p < 0.0001). For mumps, the proportion of
       vaccinated HIV+ participants with protective IgG antibody titers was
       higher among those with CD4+ lymphocyte counts < 200 cells/mm3 (p =
       0.058). For HIV+ participants < 14 years of age, this same trend was
       seen for measles and rubella, but was not seen in any age group for
       bacterial vaccine antigens. The intercorrelations among skin test
       anergy, CD4+ lymphocyte counts, serum IgA levels, and viral vaccine
       antigen-related serologic titers for HIV+ participants are consistent
       with an association between progressive HIV-related immune dysfunction
       and a predominance of type II (humoral immunity) or Type 0 (mixed
       immunity), relative to type I, lymphocyte profiles.
 DE    Adolescence  Child  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Disease
       Progression  Female  Hemophilia/COMPLICATIONS  Human  Hypersensitivity,
       Delayed/IMMUNOLOGY  HIV Infections/COMPLICATIONS/*IMMUNOLOGY  HIV
       Seronegativity/IMMUNOLOGY  HIV Seropositivity/IMMUNOLOGY  IgA/IMMUNOLOGY
       Immunity, Cellular  Male  Skin Tests  Support, U.S. Gov't, P.H.S.  Th1
       Cells/*PHYSIOLOGY/VIROLOGY  Th2 Cells/*PHYSIOLOGY/VIROLOGY  Viral
       Vaccines/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

