       Document 0836
 DOCN  M9620836
 TI    IgE levels in pediatric HIV-1 infection.
 DT    9602
 AU    Ellaurie M; Rubinstein A; Rosenstreich DL; Children's National Medical
       Center, Special Immunology Service,; Washington, DC, USA.
 SO    Ann Allergy Asthma Immunol. 1995 Oct;75(4):332-6. Unique Identifier :
       AIDSLINE MED/96026133
 AB    BACKGROUND: Atopic symptoms such as sinusitis, eczema, and wheezing are
       common in human immunodeficiency virus (HIV)-infected children.
       OBJECTIVE: To determine whether IgE levels are increased in
       HIV-seropositive children, and to determine whether there is a
       relationship between IgE, stage of disease, and atopic symptoms.
       METHODS: Levels of serum IgE and parameters of HIV infection, including
       absolute CD4 and CD8 T lymphocyte counts, and serum levels of neopterin,
       beta 2 microglobulin and HIV P24 antigen were measured. Clinical
       parameters including stage of disease, opportunistic infections, and
       atopic symptoms were recorded. RESULTS: IgE was increased prior to 1
       year of age and mean levels remained elevated through age 6 years but
       regressed to the normal mean in children ages 7 to 9. There was a strong
       association between increased IgE and the presence of secondary
       disseminated or systemic diseases including pulmonary lymphoid
       hyperplasia, Pneumocystis carinii pneumonia, or disseminated
       cytomegalovirus infection. There was no correlation between CD4 levels
       and IgE levels (r = .03). The relationship between IgE and serum P24
       antigen, beta 2 microglobulin, and neopterin levels was also analyzed. A
       weak positive correlation was found only with serum p24 antigen levels
       (r = .24). Atopic symptoms were found in a subpopulation of these
       children, with wheezing occurring in 27% of all patients, atopic
       dermatitis in 5%, drug reactions in 7% and sinusitis in 8% but IgE
       levels were not significantly elevated in patients with atopic symptoms.
       CONCLUSIONS: These findings demonstrate that serum IgE is increased in
       children very early after HIV infection and that IgE levels increase in
       association with HIV-associated systemic disease. Increased IgE is not
       associated with atopic symptoms in children.
 DE    Biological Markers/BLOOD  Child  Child, Preschool  Female  Human
       Hypersensitivity, Immediate/IMMUNOLOGY/VIROLOGY  HIV
       Infections/CLASSIFICATION/DIAGNOSIS/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       IgE/*BLOOD  Infant  Male  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

