       Document 0806
 DOCN  M9620806
 TI    Role of cell-mediated immunity in bovine leukemia virus (BLV) infection
       in ruminants: its implication for the vaccination strategy against
       retroviruses.
 DT    9602
 AU    Sugimoto M; Ohishi K; Ikawa Y; Department of Preventive Medicine,
       Nagasaki University, Japan.
 SO    Ther Immunol. 1994 Oct;1(5):297-301. Unique Identifier : AIDSLINE
       MED/96053312
 AB    Recent studies in the immunopathogenesis of bovine leukemia virus (BLV)
       infection in ruminants, reviewed herein, provide an insight into the
       vaccination strategy against retrovirus infection. It was shown that
       vaccination of naive sheep with a recombinant vaccinia virus (RVV)
       expressing BLV envelope glycoprotein protected the animals against BLV
       infection. The involvement of cell-mediated immunity (CMI) in this
       phenomenon was strongly suggested. The postinfection vaccination, that
       is, the vaccination of BLV-infected animals with RVV, also significantly
       suppressed BLV replication in the carrier animals. These findings
       support the idea that vaccination against retroviruses should put its
       emphasis on the induction of CMI and that such vaccine could be used not
       only for prophylactic but also for therapeutic purposes.
 DE    Animal  Antibodies, Viral/IMMUNOLOGY  Cattle  Enzootic Bovine
       Leukosis/*IMMUNOLOGY/PREVENTION & CONTROL  Hypersensitivity,
       Delayed/IMMUNOLOGY  *Immunity, Cellular  Leukemia Virus,
       Bovine/*IMMUNOLOGY  Lymphocyte Transformation  Sheep  Vaccination  Viral
       Vaccines/IMMUNOLOGY  Virus Replication  JOURNAL ARTICLE  REVIEW  REVIEW,
       ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

