       Document 0800
 DOCN  M9620800
 TI    Microsatellite instability in primary neoplasms from HIV + patients.
 DT    9602
 AU    Bedi GC; Westra WH; Farzadegan H; Pitha PM; Sidransky D; Department of
       Otolaryngology--Head and Neck Surgery, Johns; Hopkins University School
       of Medicine, Baltimore, Maryland; 21205-2196, USA.
 SO    Nat Med. 1995 Jan;1(1):65-8. Unique Identifier : AIDSLINE MED/96071374
 AB    AIDS is associated with a high risk of certain malignancies, notably
       Kaposi's sarcoma (KS) and B-cell non-Hodgkin's lymphoma (NHL). The
       pathogenesis of these malignancies is not fully understood. One
       mechanism of malignant transformation recently described in colon
       tumorigenesis results from defects in DNA mismatch repair, manifest as
       widespread microsatellite instability. We demonstrate a high rate of
       microsatellite instability in KS and aggressive lymphomas obtained from
       HIV-infected patients, whereas there is no evidence of instability in
       similar lesions from HIV-negative patients. Further elucidation of the
       underlying mechanisms responsible for HIV-associated instability in
       primary tumours may provide insight into the pathogenesis of these
       AIDS-related neoplasms.
 DE    DNA Repair  DNA, Neoplasm/*GENETICS  DNA, Viral/ANALYSIS  Genetic
       Markers  Human  HIV Infections/*GENETICS  Lymphoma,
       Non-Hodgkin's/*GENETICS  *Microsatellite Repeats  Sarcoma,
       Kaposi's/*GENETICS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

