       Document 0789
 DOCN  M9620789
 TI    Apoptosis occurs predominantly in bystander cells and not in
       productively infected cells of HIV- and SIV-infected lymph nodes [see
       comments]
 DT    9602
 AU    Finkel TH; Tudor-Williams G; Banda NK; Cotton MF; Curiel T; Monks C;
       Baba TW; Ruprecht RM; Kupfer A; Department of Pediatrics, National
       Jewish Center for Immunology; and Respiratory Medicine, Denver, Colorado
       80206, USA.
 SO    Nat Med. 1995 Feb;1(2):129-34. Unique Identifier : AIDSLINE MED/96071391
 CM    Comment in: Nat Med 1995 Feb;1(2):118-20
 AB    Although 13 years have passed since identification of human
       immunodeficiency virus-1 (HIV-1) as the cause of AIDS, we do not yet
       know how HIV kills its primary target, the T cell that carries the CD4
       antigen. We and others have shown an increase in the percentage of
       apoptotic cells among circulating CD4+ (and CD8+) T cells of
       HIV-seropositive individuals and an increase in frequency of apoptosis
       with disease progression. However, it is not known if this apoptosis
       occurs in infected or uninfected T cells. We show here, using in situ
       labelling of lymph nodes from HIV-infected children and SIV-infected
       macaques, that apoptosis occurs predominantly in bystander cells and not
       in the productively infected cells themselves. These data have
       implications for pathogenesis and therapy, namely, arguing that rational
       drug therapy may involve combination agents targeting viral replication
       in infected cells and apoptosis of uninfected cells.
 DE    Animal  *Apoptosis  Child  Child, Preschool  Female  Human  HIV
       Infections/PATHOLOGY/*VIROLOGY  HIV-1/PATHOGENICITY  Lymph
       Nodes/*PATHOLOGY/VIROLOGY  Macaca  Male  RNA, Messenger/ANALYSIS  RNA,
       Viral/ANALYSIS  Simian Acquired Immunodeficiency
       Syndrome/PATHOLOGY/*VIROLOGY  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  SIV/PATHOGENICITY  T-Lymphocytes/VIROLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

