       Document 0776
 DOCN  M9620776
 TI    Mitochondrial toxicity of antiviral drugs.
 DT    9602
 AU    Lewis W; Dalakas MC; Department of Pathology and Laboratory Medicine,
       University of; Cincinnati College of Medicine, Ohio 45267-0529, USA.
 SO    Nat Med. 1995 May;1(5):417-22. Unique Identifier : AIDSLINE MED/96071467
 AB    Long-term treatment with antiviral nucleoside analogue drugs, such as
       AZT, can give rise to delayed and at times severe mitochondrial
       toxicity. Although these toxic effects are manifest in many tissues, a
       common disease mechanism can explain the diverse clinical events. A
       better understanding of these disorders will shed light on genetic
       mitochondrial diseases and lead to the design of safer and more
       effective antiviral drugs.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/DRUG THERAPY  Animal
       Antiviral Agents/ADVERSE EFFECTS/CHEMISTRY/*TOXICITY
       Arabinofuranosyluracil/ANALOGS & DERIVATIVES/TOXICITY
       Didanosine/TOXICITY  DNA Polymerases/DRUG EFFECTS  DNA,
       Mitochondrial/DRUG EFFECTS  Human  Mitochondria/*DRUG EFFECTS  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Zalcitabine/TOXICITY
       Zidovudine/TOXICITY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

