       Document 0757
 DOCN  M9620757
 TI    Long-term protection against SIV-induced disease in macaques vaccinated
       with a live attenuated HIV-2 vaccine.
 DT    9602
 AU    Putkonen P; Walther L; Zhang YJ; Li SL; Nilsson C; Albert J; Biberfeld
       P; Thorstensson R; Biberfeld G; Department of Immunology, Swedish
       Institute for Infectious; Disease Control, Karolinska Institute,
       Stockholm, Sweden.
 SO    Nat Med. 1995 Sep;1(9):914-8. Unique Identifier : AIDSLINE MED/96071597
 AB    The aim of this study was to test the ability of a live attenuated human
       immunodeficiency virus type 2 (HIV-2) vaccine to protect cynomolgus
       monkeys against superinfection with a pathogenic simian immunodeficiency
       virus (SIVsm). This report is an update on our previously reported
       observation period of nine months. The new data here show that three of
       four monkeys vaccinated with live HIV-2 were protected against
       immunosuppression and SIV-induced disease during more than five years of
       follow-up. The quality of the immunity was permissive for infection, but
       monkeys that survived showed restricted viral replication in peripheral
       blood and lymph nodes. This study shows that it is possible to induce
       protection against a pathogenic heterologous primate lentivirus and to
       prevent disease in vaccinated monkeys even if infection is not
       prevented. These findings provide evidence that protection against AIDS
       can be achieved by immunization.
 DE    Animal  Antibodies, Viral/BIOSYNTHESIS  AIDS Vaccines/*IMMUNOLOGY
       Female  Human  HIV-2/*IMMUNOLOGY  Macaca fascicularis  Male  Polymerase
       Chain Reaction  Simian Acquired Immunodeficiency
       Syndrome/IMMUNOLOGY/*PREVENTION  & CONTROL  Support, Non-U.S. Gov't
       SIV/*IMMUNOLOGY  *Vaccination  Vaccines, Attenuated/IMMUNOLOGY  Viral
       Interference  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

