       Document 0756
 DOCN  M9620756
 TI    CD26 expression correlates with entry, replication and cytopathicity of
       monocytotropic HIV-1 strains in a T-cell line [see comments]
 DT    9602
 AU    Oravecz T; Roderiquez G; Koffi J; Wang J; Ditto M; Bou-Habib DC; Lusso
       P; Norcross MA; Division of Hematologic Products, Food and Drug
       Administration,; National Institutes of Health, Bethesda, Maryland
       20892, USA.
 SO    Nat Med. 1995 Sep;1(9):919-26. Unique Identifier : AIDSLINE MED/96071598
 CM    Comment in: Nat Med 1995 Sep;1(9):881-2
 AB    Experiments to identify cell determinants involved in HIV-1 tropism
       revealed a specific decrease in the expression of the T-cell activation
       antigen CD26 after monocytotropic (M-tropic) but not T-cell line-tropic
       (T-tropic) virus infection of the PM1 T-cell line. The level of CD26
       expression in single-cell clones of PM1 correlated with the entry rate
       and cytopathicity of M-tropic HIV-1 variants, resulting in preferential
       survival of cells with low CD26 levels after infection. Experiments with
       recombinant viruses showed that the third hypervariable region of the
       envelope gp120 plays an important role in this selection process. This
       study identifies CD26 as a key marker for M-tropic human
       immunodeficiency virus type 1 (HIV-1) infection and suggests a mechanism
       for the early loss of CD26-expressing cells in HIV-1-infected
       individuals.
 DE    Amino Acid Sequence  Antigens, CD26/BIOSYNTHESIS/GENETICS/*PHYSIOLOGY
       Base Sequence  Cell Survival  Cells, Cultured  Cytopathogenic Effect,
       Viral  CD4-Positive T-Lymphocytes/ENZYMOLOGY/*VIROLOGY  Down-Regulation
       (Physiology)  DNA, Viral/ANALYSIS  Gene Expression Regulation, Viral
       Human  HIV Envelope Protein gp120/METABOLISM  HIV
       Infections/IMMUNOLOGY/PATHOLOGY/VIROLOGY
       HIV-1/*PHYSIOLOGY/PATHOGENICITY  Molecular Sequence Data
       Monocytes/VIROLOGY  Peptide Fragments/METABOLISM  *Receptors, Virus
       RNA, Messenger/BIOSYNTHESIS  Support, U.S. Gov't, P.H.S.  Virus
       Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

