       Document 0738
 DOCN  M9620738
 TI    A subset of splenic macrophages process and present native antigen to
       naive antigen-specific CD4+ T-cells from mice transgenic for an alpha
       beta T-cell receptor.
 DT    9602
 AU    Askew D; Gatewood J; Olivas E; Havenith K; Walker WS; Department of
       Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee
       38105, USA.
 SO    Cell Immunol. 1995 Nov;166(1):62-70. Unique Identifier : AIDSLINE
       MED/96067656
 AB    The progeny of individual macrophage precursors from mouse spleen were
       examined for their ability to constitutively process and present native
       pigeon cytochrome c or a peptide fragment of this antigen to naive CD4+
       T-cells from mice transgenic for a V alpha 11/V beta 3 TCR that
       recognizes an epitope in the antigen fragment. The results show that
       constitutive Ag processing and presentation is a stable characteristic
       restricted to the progeny of approximately 20% of splenic macrophage
       precursors. This property does not appear to be randomly acquired, but
       to reflect the ability of certain macrophages to produce IL-12.
 DE    Animal  *Antigen Presentation  Antigen-Presenting
       Cells/*IMMUNOLOGY/METABOLISM  Cytochrome c/IMMUNOLOGY  CD4 Lymphocyte
       Count  CD4-Positive T-Lymphocytes/IMMUNOLOGY/*METABOLISM
       Epitopes/IMMUNOLOGY  Histocompatibility Antigens Class II/GENETICS
       Lymphocyte Transformation  Macrophages/*IMMUNOLOGY/METABOLISM  Mice
       Mice, Inbred C57BL  Mice, Transgenic  Peptide Fragments/IMMUNOLOGY
       Pigeons  Receptors, Antigen, T-Cell, alpha-beta/*GENETICS/IMMUNOLOGY
       Spleen/*CYTOLOGY  Stem Cells/IMMUNOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

