       Document 0721
 DOCN  M9620721
 TI    A CD3+CD8+ T cell population lacking CD5 antigen expression is expanded
       in peripheral blood of human immunodeficiency virus-infected patients.
 DT    9602
 AU    Indraccolo S; Mion M; Zamarchi R; Coppola V; Calderazzo F; Amadori A;
       Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.
 SO    Clin Immunol Immunopathol. 1995 Dec;77(3):253-61. Unique Identifier :
       AIDSLINE MED/96080353
 AB    In this study we analyzed the behavior of a CD3+ T cell subpopulation
       lacking CD5 antigen expression in PBMC from HIV-1-infected patients.
       CD3+CD5- lymphocytes were greatly increased in peripheral blood of
       HIV-1+ patients, accounting for 20.6 +/- 9.9% of the total CD3+ cells,
       compared to seronegative individuals (5.5 +/- 3.2%). In both
       seropositive patients and controls, CD3+CD5- cells belonged to the CD8+
       compartment; they were nonactivated, TCR alpha/beta+, naive lymphocytes,
       and in seronegative individuals preferentially expressed NK
       cell-associated markers, such as CD11b, CD16, CD56, and CD57. The
       phenotypic profile of this subset was slightly different in seropositive
       patients; while TCR expression and CD45RA/RO profile were comparable,
       CD11b and CD16 expression was lower compared to control figures, while
       CD56 expression was not changed, and CD57 expression was enhanced.
       Functional analysis of enriched CD3+CD8+CD5- cells showed an impaired
       ability to proliferate in response to mitogenic and antigenic stimuli;
       despite their NK-like phenotype, CD3+CD8+CD5- cells did not exert any NK
       cytotoxic activity, and only a lectin-dependent cytotoxic potential
       could be evidenced in this population. These results describe a novel
       alteration in the lymphocytes phenotypic profile during HIV-1 infection,
       involving a transitional population, which shares some properties of the
       T and of the NK cell lineage.
 DE    Antigens, CD3/*ANALYSIS  Antigens, CD5/*ANALYSIS  Antigens,
       CD8/*ANALYSIS  Biological Markers/ANALYSIS  Cells, Cultured
       Cytotoxicity, Immunologic/IMMUNOLOGY  Female  Human  HIV
       Infections/BLOOD/*IMMUNOLOGY  HIV-1/IMMUNOLOGY  Immunophenotyping
       Lymphocyte Transformation/IMMUNOLOGY  Male  Support, Non-U.S. Gov't
       T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

