       Document 0719
 DOCN  M9620719
 TI    IgG autoantibody response in HTLV-I-infected patients.
 DT    9602
 AU    Muller S; Boire G; Ossondo M; Ricchiuti V; Smadja D; Vernant JC; Ozden
       S; Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Centre;
       National de la Recherche Scientifique, Strasbourg, France.
 SO    Clin Immunol Immunopathol. 1995 Dec;77(3):282-90. Unique Identifier :
       AIDSLINE MED/96080356
 AB    Human T-cell leukemia virus type I (HTLV-I) is associated with a large
       spectrum of clinical manifestation including adult T-cell leukemia (ATL)
       and tropical spastic paraparesis or HTLV-I-associated myelopathy
       (TSP/HAM). In most cases, however, infected patients remain
       asymptomatic. The participation of the immune system in the pathogenesis
       of TSP/HAM has been suggested. In this study the IgG antibody response
       of HTLV-I-infected individuals has been investigated using both ELISA
       with a panel of nuclear and cytoplasmic proteins and peptides known to
       be recognized by antibodies from patients with various systemic
       autoimmune diseases, and immunoprecipitation of ribonucleoproteins from
       HeLa cell extracts. The results were compared with the reactivity of
       sera from individuals with non-HTLV-I-related neurological diseases and
       healthy blood donors. Raised levels of autoantibodies reacting with
       several nuclear and cytoplasmic antigens were found in TSP/HAM and ATL
       patients. In asymptomatic HTLV-I-seropositive individuals, both the
       prevalence and level of IgG antibodies were lower and directed only
       against a restricted set of antigens. The mechanism of induction of
       these antibodies still remains obscure. However, the results show that a
       significant autoimmune response exists in these patients and it may
       contribute to the pathogenesis of the disease.
 DE    Adult  Antibodies, Antinuclear/BLOOD/IMMUNOLOGY
       Autoantibodies/*BLOOD/*IMMUNOLOGY  Autoantigens/*IMMUNOLOGY
       Enzyme-Linked Immunosorbent Assay  Female  Hela Cells  Human  HTLV-I
       Infections/*IMMUNOLOGY  IgG/*BLOOD/*IMMUNOLOGY  Male
       Peptides/IMMUNOLOGY  Precipitin Tests  Ribonucleoproteins/IMMUNOLOGY
       RNA/IMMUNOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

