       Document 0717
 DOCN  M9620717
 TI    Differential effect of TGF-beta 1 on the in vitro activation of HTLV-I
       and the proliferative response of CD8+ T lymphocytes in patients with
       HTLV-I-associated myelopathy (HAM/TSP).
 DT    9602
 AU    Nagai M; Ijichi S; Hall WW; Osame M; Third Department of Internal
       Medicine, Faculty of Medicine,; Kagoshima University, Japan.
 SO    Clin Immunol Immunopathol. 1995 Dec;77(3):324-31. Unique Identifier :
       AIDSLINE MED/96080361
 AB    While considerable information is available on the pathogenesis of human
       T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical
       spastic paraparesis (HAM/TSP), fundamental questions remain unanswered.
       In particular the clinicopathological uniformity of the disorder among
       patients remains poorly understood. The potential role of TGF-beta as a
       preferential immune regulator in the CNS and the functional
       heterogeneity of TGF-beta has led us to assess the possible involvement
       of this cytokine in the pathogenic process. To investigate this, the
       modulatory effects of TGF-beta 1 on HTLV-I-induced in vitro phenomena
       were evaluated using fractionated lymphocytes from patients with
       HAM/TSP. It could be shown that the proliferative response of CD8+ cells
       against cultured and irradiated autologous CD4+ cells possessing HTLV-I
       antigens was significantly inhibited by TGF-beta 1. However, the in
       vitro activation of HTLV-I, which was evaluated by spontaneous
       proliferation of CD4+ cells, was unaffected by TGF-beta 1. The induction
       of intracytoplasmic HTLV-I antigens in cultured CD4+ cells was
       facilitated by TGF-beta 1 in a dose-dependent manner. These findings
       suggest that TGF-beta may have a critical role in localized viral
       activation within the CNS in patients with HAM/TSP.
 DE    Adult  Aged  Cell Line  Cells, Cultured  CD4-Positive T-Lymphocytes/DRUG
       EFFECTS/VIROLOGY  CD8-Positive T-Lymphocytes/*DRUG EFFECTS/VIROLOGY
       Female  Human  HTLV-I/*DRUG EFFECTS/IMMUNOLOGY  Lymphocyte
       Transformation/DRUG EFFECTS  Male  Middle Age  Paraparesis, Tropical
       Spastic/*IMMUNOLOGY  Transforming Growth Factor beta/*PHARMACOLOGY
       Virus Activation/*DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

