       Document 0669
 DOCN  M9620669
 TI    A Drosophila protein related to the human zinc finger transcription
       factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.
 DT    9602
 AU    Staehling-Hampton K; Laughon AS; Hoffmann FM; McArdle Laboratory for
       Cancer Research, University of Wisconsin; Medical School, Madison 53706,
       USA.
 SO    Development. 1995 Oct;121(10):3393-403. Unique Identifier : AIDSLINE
       GENBANK/U31368
 AB    Little is known about the signal transduction pathways by which cells
       respond to mammalian TGF-beta s or to decapentaplegic (dpp), a
       Drosophila TGF-beta-related factor. Here we describe the genetic and
       molecular characterization of Drosophila schnurri (shn), a putative
       transcription factor implicated in dpp signaling. The shn protein has
       eight zinc fingers and is related to a human transcription factor,
       PRDII/MBPI/HIV-EP1, that binds to nuclear factor-kappa B-binding sites
       and activates transcription from the HIV long terminal repeat (LTR). shn
       mRNA is expressed in a dynamic pattern in the embryo that includes most
       of the known target tissues of dpp, including the dorsal blastoderm, the
       mesodermal germlayer and parasegments 4 and 7 of the midgut. Mutations
       in shn affect several developmental processes regulated by dpp including
       induction of visceral mesoderm cell fate, dorsal/ventral patterning of
       the lateral ectoderm and wing vein formation. Absence of shn function
       blocks the expanded expression of the homeodomain protein bagpipe in the
       embryonic mesoderm caused by ectopic dpp expression, illustrating a
       requirement for shn function downstream of dpp action. We conclude that
       shn function is critical for cells to respond properly to dpp and
       propose that shn protein is the first identified downstream component of
       the signal transduction pathway used by dpp and its receptors.
 DE    Amino Acid Sequence  Animal  Cloning, Molecular
       Drosophila/*EMBRYOLOGY/GENETICS  DNA-Binding Proteins/*GENETICS  Insect
       Hormones/GENETICS/*PHYSIOLOGY  Mesoderm/PHYSIOLOGY  Molecular Sequence
       Data  Morphogenesis/GENETICS  Phenotype  Signal Transduction/GENETICS
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Transcription
       Factors/*GENETICS/*PHYSIOLOGY  Transforming Growth Factor
       beta/GENETICS/*PHYSIOLOGY  Wing/ANATOMY & HISTOLOGY  *Zinc Fingers
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

