       Document 0656
 DOCN  M9620656
 TI    Catheter-related cutaneous aspergillosis complicated by fungemia and
       fatal pulmonary infection in an HIV-positive patient with acute
       lymphocytic leukemia.
 DT    9602
 AU    Girmenia C; Gastaldi R; Martino P; Department of Human Biopathology,
       University La Sapienza, Rome,; Italy.
 SO    Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):524-6. Unique Identifier
       : AIDSLINE MED/96082797
 AB    A case of intravenous catheter-related cutaneous aspergillosis and
       Aspergillus fumigatus fungemia in an HIV-positive patient with
       Burkitt-cell acute lymphocytic leukemia is reported. The patient
       developed pulmonary aspergillosis with a rapidly fatal outcome despite
       recovery from neutropenia and improvement of the underlying malignancy.
       The unusual severity and rapid spread of the infection, despite normal
       neutrophil count and prompt antifungal therapy, suggest that HIV-related
       immunocompromise might play a role in the impairment of host defences
       against Aspergillus infection. Thus catheter-related cutaneous
       aspergillosis could lead to a severe deep-seated infection in
       HIV-positive patients.
 DE    Adult  Antifungal Agents/THERAPEUTIC USE
       Aspergillosis/*COMPLICATIONS/DRUG THERAPY/ETIOLOGY  Case Report
       Catheterization, Central Venous/ADVERSE EFFECTS
       Dermatomycoses/*COMPLICATIONS/DRUG THERAPY/ETIOLOGY  Disease Progression
       Fatal Outcome  Female  Fungemia/*COMPLICATIONS/DRUG THERAPY/ETIOLOGY
       Human  Leukemia, Lymphocytic, Acute/*COMPLICATIONS  Opportunistic
       Infections/*COMPLICATIONS/DRUG THERAPY  Pneumonia/*COMPLICATIONS/DRUG
       THERAPY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

