       Document 0645
 DOCN  M9620645
 TI    Apoptotic death of lymphocytes in murine acquired immunodeficiency
       syndrome: involvement of Fas-Fas ligand interaction.
 DT    9602
 AU    Kanagawa O; Vaupel BA; Korsmeyer SJ; Russell JH; Department of
       Pathology, Washington School of Medicine, St.; Louis, MO 63110, USA.
 SO    Eur J Immunol. 1995 Sep;25(9):2421-7. Unique Identifier : AIDSLINE
       MED/96011846
 AB    Murine acquired immunodeficiency syndrome (MAIDS) is caused by a
       defective murine leukemia virus. The disease is characterized by
       abnormal lymphoproliferation, impaired T and B cell function and
       aberrant regulation of cytokines. Both T and B lymphocytes show
       activated phenotypes, but undergo apoptotic death with characteristic
       DNA fragmentation. These results indicate the presence of a continuous
       activation death pathway of the lymphocytes in MAIDS. Overexpression of
       the bcl-2 transgene in lymphocytes showed no effect on the apoptotic
       cell death or on the development of the disease. In contrast, mice
       carrying mutations in either Fas or Fas ligand exhibited accelerated
       progression of the disease upon infection with MAIDS virus. These
       results suggest the involvement of Fas-Fas ligand system in the
       pathogenesis of MAIDS.
 DE    Animal  Antigens, CD95/GENETICS/IMMUNOLOGY  Apoptosis/*IMMUNOLOGY
       B-Lymphocytes/*IMMUNOLOGY/PATHOLOGY  Cells, Cultured
       Endo-1,3-beta-Glucanase/BIOSYNTHESIS  Immunophenotyping  Ligands  Mice
       Mice, Inbred C57BL  Mice, Transgenic  Murine Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY/METABOLISM/  PATHOLOGY  Mutation  Support, U.S.
       Gov't, P.H.S.  T-Lymphocytes/*IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

