       Document 0613
 DOCN  M9620613
 TI    HIV-1 incidence and HIV-1 associated mortality in a cohort of urban
       factory workers in Tanzania.
 DT    9602
 AU    Borgdorff MW; Barongo LR; Klokke AH; Newell JN; Senkoro KP; Velema JP;
       Gabone RM; National Institute for Medical Research, Mwanza, Tanzania.
 SO    Genitourin Med. 1995 Aug;71(4):212-5. Unique Identifier : AIDSLINE
       MED/96046496
 AB    OBJECTIVE--To determine HIV-1 incidence and HIV-1 associated mortality
       in a prospective cohort study. To determine whether the cohort is
       suitable for studies aiming to determine the impact of interventions on
       HIV-1 incidence. METHODS--The study population was a cohort of 1772
       urban factory workers (1478 men and 294 women) in northwest Tanzania.
       The study took place from October 1991 to September 1993. Outcome
       measures were HIV-1 seroconversion and death. RESULTS--HIV-1 incidence
       was 1.2 (95% CI 0.7-2.0) per 100 person-years (pyr). Crude annual
       mortality was 4.9 per 100 pyr in those with and 0.3 in those without
       HIV-1 infection, giving an age and sex adjusted mortality ratio of 12.9
       (95% CI 5.4-30.7). Of all deaths, 62% were attributable to HIV-1
       infection. CONCLUSION--HIV-1 infection was a major public health
       problem, being the major cause of death in this adult population. At an
       HIV-1 incidence of 1.2 per 100 pyr, a large cohort size would be
       required to evaluate the impact of interventions on HIV-1 incidence.
 DE    Adolescence  Adult  Aged  Cohort Studies  Female  Human  HIV
       Infections/EPIDEMIOLOGY/*MORTALITY  *HIV-1  Incidence  Male  Middle Age
       Prevalence  Random Allocation  Risk Factors  Support, Non-U.S. Gov't
       Survival Rate  Tanzania/EPIDEMIOLOGY  Urban Health  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

