       Document 0610
 DOCN  M9620610
 TI    Herpes simplex virus type 2 encephalitis and concomitant cytomegalovirus
       infection in a patient with AIDS: detection of virus-specific DNA in CSF
       by nested polymerase chain reaction.
 DT    9602
 AU    Miller RF; Fox JD; Waite JC; Severn A; Brink NS; Department of Medicine,
       University College London Medical School,; Middlesex Hospital, London,
       UK.
 SO    Genitourin Med. 1995 Aug;71(4):262-4. Unique Identifier : AIDSLINE
       MED/96046509
 AB    A Caucasian homosexual man with AIDS and cytomegalovirus retinitis
       presented with facial pain and episodic confusion, had several seizures
       and became obtunded. An electroencephalogram was suggestive of herpes
       simplex encephalitis. The diagnosis was confirmed by detection of herpes
       simplex virus type 2 (HSV 2), but not type 1, DNA in cell-free
       cerebrospinal fluid (CSF) after amplification by nested polymerase chain
       reaction. The patient also had evidence of concomitant cytomegalovirus
       (CMV) infection with detectable CMV DNA in CSF. With high-dose acyclovir
       the patient recovered. Analysis of a follow up CSF sample taken four
       months later showed no detectable HSV-2 DNA.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Acyclovir/THERAPEUTIC
       USE  Case Report  Cytomegalovirus Infections/CEREBROSPINAL
       FLUID/*COMPLICATIONS/  DIAGNOSIS/DRUG THERAPY  DNA, Viral/CEREBROSPINAL
       FLUID  Encephalitis, Viral/*COMPLICATIONS/ETIOLOGY  Herpes
       Simplex/*COMPLICATIONS/DIAGNOSIS/DRUG THERAPY  Human  Male  Middle Age
       Polymerase Chain Reaction  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

