       Document 0606
 DOCN  M9620606
 TI    Serum nitrite plus nitrate in infection with human immunodeficiency
       virus type-1.
 DT    9602
 AU    Zangerle R; Fuchs D; Reibnegger G; Werner-Felmayer G; Gallati H; Wachter
       H; Werner ER; Department of Dermatology and Venereology, University of;
       Innsbruck, Ludwig Boltzmann Institute of AIDS Research, Austria.
 SO    Immunobiology. 1995 Jun;193(1):59-70. Unique Identifier : AIDSLINE
       MED/96100679
 AB    To get a measure of the extent of induction of nitric oxide synthase in
       infection with human immunodeficiency virus type-1 (HIV-1) in vivo, we
       estimated serum nitrite plus nitrate concentrations in 110 HIV-1
       infected individuals compared to 76 blood donors. To monitor cytokine
       action and to measure induction of pteridine synthesis, we determined in
       parallel neopterin, biopterin, soluble tumor necrosis factor-alpha
       receptor 55 and 75, and beta 2-microglobulin. Serum nitrite plus nitrate
       concentrations were elevated in patients as compared to blood donor
       controls. In sera of patients, nitrite plus nitrate levels correlated
       significantly with neopterin, soluble tumor necrosis factor receptor 55
       and 75, and beta 2-microglobulin. Nitrite plus nitrate levels were
       higher and correlations were stronger in groups of patients with lower
       CD4+ cell count. These results suggest that cytokine-mediated nitric
       oxide synthesis occurs in individuals with HIV-1 infection.
 DE    beta 2-Microglobulin/ANALYSIS  Adult  Biological Markers/*BLOOD
       Biopterin/ANALOGS & DERIVATIVES/BLOOD  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  Female  Human  HIV
       Infections/*BLOOD/IMMUNOLOGY  Male  Nitrates/*BLOOD  Receptors, Tumor
       Necrosis Factor/ANALYSIS  Sodium Nitrite/*BLOOD  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

