       Document 0510
 DOCN  M9620510
 TI    CD4+ lymphocytes in perinatal human immunodeficiency virus (HIV)
       infection: evidence for pregnancy-induced immune depression in
       uninfected and HIV-infected women.
 DT    9602
 AU    Rich KC; Siegel JN; Jennings C; Rydman RJ; Landay AL; Department of
       Pediatrics, University of Illinois at Chicago; 60612, USA.
 SO    J Infect Dis. 1995 Nov;172(5):1221-7. Unique Identifier : AIDSLINE
       MED/96036377
 AB    Immune function changes during pregnancy and human immunodeficiency
       virus (HIV) infection. T helper function and phenotypes in HIV-infected
       and -uninfected pregnant and postpartum women and nonpregnant uninfected
       control women were studied. T helper function was assessed by
       interleukin-2 (IL-2) production in vitro and three-color flow cytometry.
       All uninfected nonpregnant subjects, 74% of uninfected pregnant
       subjects, and only 54% of HIV-infected pregnant subjects responded to
       all stimuli. All uninfected subjects 2-6 months postpartum had normal
       function versus 27% of infected subjects (trend P < .001). Uninfected
       pregnant subjects had reduced levels of CD4+CD45RA-RO+ (memory) and
       elevated levels of CD4+CD45RA+RO- (naive) lymphocytes. Infected pregnant
       subjects had elevated levels of memory, reduced levels of naive, and
       increased levels of CD4+HLA-DR+CD38+ (activated) lymphocytes. Increased
       CD4+DR+CD38+ cells correlated best with poor IL-2 function, HIV
       infection, and being postpartum (R2 = .79). Thus, T helper function and
       phenotypes are altered in pregnancy and return to baseline postpartum in
       uninfected but not HIV-infected women.
 DE    Antigens, CD/BLOOD  Antigens, CD4/BLOOD  Antigens, CD45/BLOOD  Antigens,
       Differentiation/BLOOD  Case-Control Studies  Cohort Studies  Comparative
       Study  CD4-Positive T-Lymphocytes/*IMMUNOLOGY  Female  Human  HIV
       Infections/*IMMUNOLOGY  HIV Seronegativity/IMMUNOLOGY  *Immune Tolerance
       Immunophenotyping  Interleukin-2/BIOSYNTHESIS  Nucleosidases/BLOOD
       Pregnancy/*IMMUNOLOGY  Pregnancy Complications,
       Infectious/*IMMUNOLOGY/*VIROLOGY  Puerperium/*IMMUNOLOGY  Support, U.S.
       Gov't, P.H.S.  T-Lymphocytes, Helper-Inducer/IMMUNOLOGY  JOURNAL ARTICLE
       MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

