       Document 0506
 DOCN  M9620506
 TI    Differential effect of human immunodeficiency virus infection on the IgA
       and IgG antibody responses to pneumococcal vaccine.
 DT    9602
 AU    Mascart-Lemone F; Gerard M; Libin M; Crusiaux A; Franchioly P;
       Lambrechts A; Goldman M; Clumeck N; Department of Immunology, Hopital
       Erasme, Brussels, Belgium.
 SO    J Infect Dis. 1995 Nov;172(5):1253-60. Unique Identifier : AIDSLINE
       MED/96036381
 AB    The IgA, IgM, and IgG antibody responses to pneumococcal polysaccharide
       vaccine were analyzed in 35 asymptomatic or mildly symptomatic human
       immunodeficiency virus (HIV)-infected patients stratified according to
       their CD4 cell counts and in 12 healthy controls. Both the antibody
       titers in serum and saliva and the numbers of circulating
       antigen-specific antibody-producing cells (Elispot technique) were
       measured. At the peak of the antibody responses, HIV-infected patients
       mounted nearly normal IgG responses, while their IgM responses were
       significantly depressed, regardless of their CD4 cell counts. The IgA
       antibody response was decreased in patients with < 500 CD4 circulating
       cells/mm3. Most IgG antibodies belonged to the IgG2 subclass, and most
       IgA antibodies were dimeric IgA2 in both controls and patients.
       Anti-capsular pneumococcal polysaccharide IgG titers decreased much more
       rapidly in HIV-infected patients so that in all groups they were
       significantly lower than in controls 9 months after vaccination.
 DE    Adult  Antibodies, Bacterial/BIOSYNTHESIS/*BLOOD  Antibody Formation
       Bacterial Vaccines/*IMMUNOLOGY  Comparative Study  Enzyme-Linked
       Immunosorbent Assay  Female  Human  HIV Infections/BLOOD/*IMMUNOLOGY
       HIV Seronegativity  HIV Seropositivity/BLOOD/*IMMUNOLOGY
       IgA/BIOSYNTHESIS/*BLOOD  IgG/BIOSYNTHESIS/*BLOOD  Immunization  Male
       Middle Age  Polysaccharides, Bacterial/*IMMUNOLOGY  Streptococcus
       pneumoniae/*IMMUNOLOGY  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

