       Document 0505
 DOCN  M9620505
 TI    Constitutive expression of major histocompatibility complex class II
       antigens on monocytes and B cells correlates with disease in simian
       immunodeficiency virus-infected rhesus macaques.
 DT    9602
 AU    Ashworth LA; Hall GA; Sharpe SA; Dennis MJ; Thornton C; Cook RW; Smith
       H; Cranage MP; Centre for Applied Microbiology and Research, Salisbury,
       United; Kingdom.
 SO    J Infect Dis. 1995 Nov;172(5):1261-7. Unique Identifier : AIDSLINE
       MED/96036382
 AB    Constitutive host factors that influence progression to AIDS are
       understood poorly. In the macaque model for AIDS, 35 animals infected
       with simian immunodeficiency virus (SIV) were analyzed for major
       histocompatibility complex class II antigen expression on blood
       monocytes and B cells by immunostaining and flow cytometry. Expression
       varied widely between animals but was constant with time. Level of
       expression and the proportion of monocytes and B cells that expressed
       class II were not affected by SIV infection. Significantly more animals
       developed AIDS in the group with low class II expression than in the
       group with high expression (P < .001). Progression to disease was faster
       in animals that expressed poorly (P < .01), and opportunistic pathogens
       were more common (P < .05). Thus, the constitutive level of class II
       antigen expression may be a useful prognostic indicator for human
       immunodeficiency virus disease in humans and may be an important factor
       in the design of vaccine trials.
 DE    Animal  AIDS Vaccines  B-Lymphocytes/*IMMUNOLOGY  Comparative Study
       Disease Progression  Drug Design  Female  Flow Cytometry
       Histocompatibility Antigens Class II/*BIOSYNTHESIS/BLOOD  Human  HIV
       Infections/IMMUNOLOGY  Macaca mulatta  Male  Monocytes/*IMMUNOLOGY
       Opportunistic Infections/ETIOLOGY/IMMUNOLOGY  Simian Acquired
       Immunodeficiency Syndrome/COMPLICATIONS/  *IMMUNOLOGY/PHYSIOPATHOLOGY
       Support, Non-U.S. Gov't  *SIV  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

