       Document 0503
 DOCN  M9620503
 TI    Prolonged shedding of amantadine-resistant influenzae A viruses by
       immunodeficient patients: detection by polymerase chain
       reaction-restriction analysis.
 DT    9602
 AU    Klimov AI; Rocha E; Hayden FG; Shult PA; Roumillat LF; Cox NJ; Influenza
       Branch, Centers for Disease Control and Prevention,; Atlanta, Georgia
       30333, USA.
 SO    J Infect Dis. 1995 Nov;172(5):1352-5. Unique Identifier : AIDSLINE
       MED/96036396
 AB    Consecutive A (H3N2) influenza virus isolates from 2 influenza
       virus-infected immunodeficient patients treated with amantadine were
       examined using a novel polymerase chain reaction (PCR)-restriction
       analysis for resistance to this antiviral compound. The data indicate
       that immunodeficient patients may shed resistant viruses for prolonged
       periods and with different drug resistance mutations present at
       different times. This PCR-restriction technique allows rapid detection
       of amantadine- or rimantadine-resistant strains.
 DE    Adult  Amantadine/*PHARMACOLOGY  Antiviral Agents/*PHARMACOLOGY  Base
       Sequence  Bone Marrow Transplantation/*IMMUNOLOGY  Case Report  Drug
       Resistance, Microbial  DNA Primers  Female  Human  Immunosuppression
       Infant, Newborn  Influenza/*ETIOLOGY/VIROLOGY  Leukemia, Myelocytic,
       Acute/THERAPY  Male  Molecular Sequence Data  Orthomyxovirus Type A,
       Human/DRUG EFFECTS/GENETICS/*ISOLATION &  PURIF  Polymerase Chain
       Reaction/*METHODS  Severe Combined
       Immunodeficiency/*COMPLICATIONS/THERAPY  *Virus Shedding  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

